Objective To observe the effect of Modified Buzhong Yiqi Decoction on pain level and knee joint function in patients with periarticular bone contusion of the knee. Methods A total of 98 patients with periarticular bone contusion admitted from April 2022 to April 2025 were selected and divided into the conventional group (n=49) and the experimental group (n=49) by random number table method.There were no cases of loss to follow-up or dropping out during the process,and all completed the study.The conventional group was treated with conventional therapy,while the experimental group was supplemented with Modified Buzhong Yiqi Decoction on the basis of conventional therapy for two consecutive weeks.The total effective rate,bone marrow edema score,Visual Analogue Scale (VAS) for pain,Lysholm score,Traditional Chinese Medicine(TCM) symptom score,incidence of adverse reactions,and matrix metalloproteinase 2 (MMP-2),tumor necrosis factor -α (TNF-α),and matrix metalloproteinase 9 (MMP-9) between the two groups were compared. Results The total effective rate of the experimental group (93.88%) was higher than that of the conventional group (79.59%) (P<0.05).There was no statistically significant difference in the VAS score,bone marrow edema score,Lysholm score and TCM symptom score before treatment between the two groups (P>0.05).Compared with before treatment,the VAS scores,TCM symptom scores,and bone marrow edema scores of both groups decreased at 2 weeks and 8 weeks of treatment,and the scores of the experimental group at 2 weeks and 8 weeks of treatment were lower than those of the conventional group (P<0.05).Compared with before treatment,the Lysholm scores of both groups increased at 2 weeks and 8 weeks of treatment,and the scores of the experimental group were higher than those of the conventional group at 2 weeks and 8 weeks of treatment (P<0.05).There was no statistically significant difference in TNF-α,MMP-2 and MMP-9 between the two groups before treatment (P>0.05).Compared with before treatment,TNF-α,MMP-2 and MMP-9 in both groups decreased at 2 weeks and 8 weeks of treatment,and those in the experimental group were lower than those in the conventional group at 2 weeks and 8 weeks of treatment (P<0.05).The total incidence of adverse reactions in the experimental group (10.20%) was not statistically different from that in the conventional group (4.08%) (P>0.05). Conclusion Modified Buzhong Yiqi Decoction can alleviate pain and bone marrow edema and improve knee joint function in patients with periarticular bone contusion of the knee.

Thrombocytopenia related to tumor treatment can lead to bleeding, blood transfusion, program adjustment, delayed treatment, interruption and other adverse consequences, which seriously affects the anti-tumor efficacy and disease outcome. There are a variety of risk factors, involving local treatment factors, systemic treatment factors and patients' own factors. Appropriate adjustment of the treatment plan for patients with multiple risk factors may reduce the incidence and severity of thrombocytopenia caused by tumor treatment, so as to ensure the continuity of tumor treatment, improve the efficacy and extend it. Always survive. The author reviews the research progress of various risk factors related to thrombocytopenia related to tumor treatment, in order to help comprehensive clinical evaluation and provide reference for screening the treatment plan that is most conducive to patients.

Surface electromyography is a technology used to detect muscle status, which is widely used in rehabilitation medicine, such as assessing muscle function status and evaluating rehabilitation efficacy, etc. This article reviews the application of surface electromyography in muscle function evaluation and curative effect evaluation of clinical diseases, in order to provide guidance for rehabilitation treatment.

Objective To analyze the application value of Red-Furnace Muscle-Pulling therapy combined with neck rehabilitation exercises in mixed-type cervical spondylosis. Methods A total of 60 patients with mixed CS admitted to our hospital from August 2024 to August 2025 were selected and divided into the control group (30 cases) and the observation group (30 cases) by random number table method.On the basis of conventional intervention measures,the control group was given neck rehabilitation exercise,and the observation group was given red furnace tendon drawing therapy combined with neck rehabilitation exercise in addition to the control group′s intervention.The treatment course was 10 days.The rehabilitation effects and recovery indicators of the two groups were compared; Before and after the intervention,the scores of the Cervical spondylosis Efficacy Score Sheet,the quality of life Cervical Spondylosis Clinical Evaluation Scale (CASCS) and the satisfaction levels of the two groups of interventions were compared. Results Compared with the control group,the rehabilitation effect and intervention satisfaction of the observation group were higher (P<0.05); Compared with the control group,the disappearance time of cervical pain and the recovery time of activity function in the observation group were shorter (P<0.05).After the intervention,the therapeutic effect score and CASCS score of cervical spondylosis in both groups increased,and the observation group was higher than the control group (P<0.05). Conclusion The application of red furnace tendon pulling therapy combined with neck rehabilitation exercises in patients with mixed CS has a definite effect.It can promote the disappearance of pain,improve cervical spine function and quality of life,and increase patient satisfaction.

With the progress of surgical technology and the emergence of new arthroscopic equipment, minitrauma arthroscopic technique has been widely used in knee surgery. Compared with open surgery, arthroscopic knee surgery greatly reduces surgical trauma and postoperative pain. However, due to the injury of joint tissue caused by instruments and stimulation of joint cavity caused by washing fluid, different degrees of postoperative pain may still occur. At present, there are many methods for pain control after arthroscopic knee surgery, including periarticular local infiltration analgesia, peripheral nerve block, intravenous analgesia, intrathecal analgesia and multimodal analgesia. Selecting appropriate postoperative analgesia and promoting early postoperative functional exercise have become the focus of anesthesiologists. Therefore, this paper reviews the various analgesia methods after knee arthroscopy and their respective advantages and disadvantages.

Objective To explore the application value of Zhuyu Zhixue Tang for patients with blood stasis syndrome and metronidazole leakage based on the Ponzi gynecological concept. Methods 103 patients with blood stasis syndrome and collapse and leakage admitted to our hospital from January 2024 to August 2025 were selected as the research subjects. They were randomly divided into a control group (51 cases) and an experimental group (52 cases) using a random number table method. The control group received Western medicine treatment, while the experimental group received combined treatment with Zhuyu Zhixue Tang based on the Ponzi gynecological concept. The clinical symptoms, coagulation fibrinolysis system function, uterine hemodynamics, hormone levels, and incidence of complications of the two groups of patients were compared. Results After treatment, the syndrome scores of dark purple menstrual blood, lower abdominal pain, dull complexion, and incomplete dripping in the experimental group were lower than those in the control group (P<0.05). The D-dimer (D-D), fibrinogen (FIB), prothrombin time (PT), and activated partial thromboplastin time (APTT) in the experimental group were all lower than those in the control group (P<0.05). The uterine artery pulsatility index (PI), resistance index (RI), and peak systolic velocity/end diastolic velocity (S/D) of the experimental group were all lower than those of the control group (P<0.05). The levels of luteinizing hormone (LH) and progesterone (P) during ovulation in the experimental group were higher than those in the control group, while estradiol (E2) was lower than that in the control group (P<0.05). The incidence of complications in the experimental group was 9.62%, which was lower than the 25.49% in the conventional group (P＜0.05). Conclusion Based on the Ponzi gynecological concept, the application of Zhuyu Zhixue Tang as an auxiliary treatment for blood stasis syndrome with collapse and leakage is beneficial for improving patients' clinical symptoms, coagulation fibrinolysis system function, and uterine hemodynamics. It has a positive impact on stabilizing patients' ovulation hormone levels and reducing the risk of complications.

Objective To explore the current status of chronic disease resource utilization among elderly patients with coronary heart disease (CHD) and its influencing factors. Methods Using a convenience sampling method,102 elderly CHD patients admitted to Tianjin Chest Hospital from August 2023 to August 2024 were selected as study subjects.Patients were surveyed using a general information questionnaire and a chronic disease social resource utilization questionnaire.Multiple linear regression analysis was used to identify factors influencing resource utilization. Results The total social resource score of elderly CHD patients was (52.34±7.56),with the highest average scores in items related to healthcare personnel and the lowest scores in organizational items.Univariate analysis showed that elderly CHD patients with different occupations,types of medical insurance,long-term residence,use of outpatient medical assistance policies,use of inpatient medical assistance policies,and use of temporary aid policies had significant differences in social resource utilization (P<0.05).Multiple linear regression analysis indicated that type of medical insurance,long-term residence,use of outpatient medical assistance policies,use of inpatient medical assistance policies,and use of temporary aid policies were influencing factors for elderly CHD patients (P<0.05). Conclusion Resource utilization among elderly CHD patients is suboptimal.Type of medical insurance,long-term residence,and the use of outpatient,inpatient,and temporary medical assistance policies are factors influencing social resource utilization.Therefore,effective interventions targeting these factors should be implemented in clinical practice.

Objective To explore the diagnostic value of fibroblast growth factor 2 (FGF-2) and miR-215 in early gastric cancer, and to analyze their predictive value for recurrence after endoscopic submucosal dissection in patients. Method 90 early gastric cancer patients admitted to our hospital from January 2018 to January 2021 were selected as the study subjects and divided into an observation group. In addition, 90 volunteers who were confirmed as normal gastric mucosa through pathological biopsy during the same period were selected and divided into a control group. Compare the expression levels of FGF-2 and miR-215 between two groups of subjects, and establish a receiver operating characteristic (ROC) curve to analyze the diagnostic efficacy of FGF-2 and miR-215 in early gastric cancer. 90 patients with early gastric cancer were treated with endoscopic submucosal dissection. After surgery, patients were followed up and divided into two subgroups based on their recurrence status: the recurrent group (n=20) and the non recurrent group (n=70). The general clinical conditions of the two groups of patients were compared, and logistic regression analysis was used to analyze the predictive value of FGF-2 and miR-215 for recurrence in early gastric cancer patients after endoscopic submucosal dissection. Results The positive rate and expression level of FGF-2 in the gastric mucosa of the observation group were significantly higher than those of the control group, and the positive rate and expression level of miR-215 were significantly lower than those of the control group (P<0.05); The diagnostic efficiency of FGF-2 for early gastric cancer is significantly higher than that of miR-215 (P<0.05). The area under the curve of FGF-2 for early gastric cancer diagnosis is 0.852, with an optimal diagnostic threshold of 1.11, an area under the curve of miR-215 is 0.735, and an optimal diagnostic threshold of 0.86; There was a significant difference in infiltration depth, tissue differentiation, FGF-2 and miR-215 levels between the recurrent and non recurrent groups (P<0.05); The results of logistic regression analysis showed that FGF-2 and miR-215 were independent prognostic factors for gastric cancer patients (P<0.05). Conclusion FGF-2 and miR-215 have high diagnostic value for early gastric cancer, and an increase in FGF-2 levels and a decrease in miR-215 levels are independent predictive factors for recurrence of early gastric cancer after endoscopic submucosal dissection.

Objective To investigate the effects and mechanisms of processed Polygonatum derived from a novel combined processing technology with Rehmannia glutinosa on learning and memory functions in D-galactose-induced aging rats. Methods SD male rats were randomly divided into five groups (n=12 per group): blank control, model, Ginkgo biloba tablet (0.01 g/kg), novel-processed Polygonatum (1.95 g/kg), and traditionally-processed Polygonatum (1.95 g/kg). Except for the blank control group receiving subcutaneous normal saline, all other groups received subcutaneous injections of D-galactose (200 mg/kg) for 8 consecutive weeks to establish aging models. Starting from the 5th week of modeling, rats were administered corresponding drugs or normal saline by gavage for 4 consecutive weeks. On days 26 and 28 of administration, Morris water maze tests were conducted to evaluate escape latency and spatial probe trials. Following the experiment, serum was collected to determine malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) levels. Brain tissues were harvested, fixed, sectioned, and stained with hematoxylin-eosin (H&E) to observe pathological changes in the cerebral cortex and hippocampal CA1 region,so as to compare the anti-aging effects and effects on learning and memory impairment between the old polygonatum group and the new polygonatum group. Results Compared with the blank control group, rats in the model group exhibited typical aging characteristics including sparse hair, slow movement, and lethargy; body weight was significantly lower from the 2nd week onward (P<0.01); escape latency was prolonged and platform crossing frequency decreased (P<0.01); serum MDA increased while SOD and GSH-Px activities decreased (P<0.01); cortical and hippocampal neurons displayed disordered arrangement with nuclear pyknosis and blurred cellular structures. Compared with the model group, all drug-treated groups showed significant improvements: body weight recovered from the 6th week (P<0.05 or P<0.01); escape latency shortened and platform crossings increased (P<0.01); MDA decreased while SOD and GSH-Px increased (P<0.01); neuronal structural integrity improved with alleviated cellular damage. Between the two processed Polygonatum groups, except that escape latency in the novel-processed group was significantly shorter than that in the traditionally-processed group (P<0.05), no significant differences were observed in other indices. Conclusion This novel combined processing technology for Rehmannia glutinosa and Polygonatum retains antioxidant and anti-aging efficacy comparable to traditional processing methods.Meanwhile, it substantially reduces processing time and resource consumption, demonstrating excellent application potential.

Vascular calcification (VC) represents a critical pathological process underlying the persistently high cardiovascular mortality in patients undergoing maintenance hemodialysis (MHD). The traditional "calcium-phosphorus product" theory is insufficient to fully elucidate its complex mechanism. This article proposes a novel paradigm of "microinflammation-bone metabolism crosstalk", systematically elaborating how the bidirectional vicious cycle formed between these two factors synergistically drives the osteogenic transdifferentiation of vascular smooth muscle cells. On one hand, chronic microinflammation exacerbates bone metabolic disorders and hyperphosphatemia by modulating the RANKL/RANK/OPG system, inducing hormone resistance, and promoting oxidative stress. This is accompanied by reduced secretion of the enteric hormone FGF19, further disrupting the delicate balance of vitamin D metabolism. On the other hand, bone-derived factors (such as FGF23-Klotho axis imbalance, hyperphosphatemia, calciprotein particles, etc.) and endogenous danger signals like uric acid crystals feedback to activate innate immune and inflammatory pathways. Both sides synergistically act on common downstream pathways, including BMP-2/Wnt and the NLRP3 inflammasome, leading to uncontrollable and progressive VC. Furthermore, this article discusses multimodal therapeutic strategies targeting key nodes (e.g., Klotho, IL-1β, FGF19/FGF23 balance), providing a new theoretical basis and potential translational directions for the prevention and treatment of VC in MHD patients.

Diabetic foot is one of the most common,severe chronic complications of diabetes mellitus,characterized by high incidence,high disability rate,and high mortality,imposing a tremendous burden on patients′ quality of life,medical resources,and socioeconomic factors.In recent years,medical institutions at all levels in Qingdao have accumulated rich experience in the diagnosis,treatment,and rehabilitation of diabetic foot.This consensus integrates the latest international guidelines and domestic research findings to establish a locally tailored diagnostic and therapeutic model.The Diabetic Foot and Chronic Wound Multidisciplinary Joint Professional Committee of the Qingdao Medical Association organized experts in this field within Qingdao to formulate the “Qingdao expert consensus on the diagnosis and treatment of diabeticfoot” through online and offline meetings,incorporating local prevention and treatment experience.It aims to provide comprehensive guidance for the diagnosis,treatment,and management of diabetic foot.The consensus places core emphasis on lower limb blood supply assessment and reconstruction therapy,highlighting a “Qingdao-style” practice pathway for diabetic foot diagnosis and treatment.

Objective To explore the effects of two anticoagulants,sodium citrate and heparin,on the coagulation function of patients in autologous blood transfusion. Methods The changes in coagulation indicators before and after autologous blood transfusion with different anticoagulants were monitored and statistically analyzed. Results When the volume of autologous blood transfusion was less than 600 ml,both anticoagulants had no significant effect on the coagulation indicators of patients (P＞0.05).When the volume of autologous blood transfusion was greater than 900 ml,the ACT,PT,and APTT indicators were significantly prolonged compared with those before transfusion (P＜0.05).When the volume of autologous blood transfusion reached 1200 ml,the effect of heparin anticoagulation on coagulation function was significantly greater than that of sodium citrate (P＜0.05),and there was no significant difference in the anticoagulation effect between the two anticoagulants (P＞0.05). Conclusion The residual anticoagulant in autologous blood transfusion during surgery has a small effect on the coagulation function of patients.Sodium citrate and heparin have the same anticoagulation effect,and sodium citrate is safer when the volume of autologous blood transfusion is large.

With the younger age of onset of gynecological malignant tumors and the postponement of the reproductive age of women, a considerable number of women of childbearing age still have the need to reproduce when they are diagnosed with malignant tumors. The problem of fertility preservation has gradually received attention in the treatment of gynecological malignancies.This article combines relevant domestic and foreign literature to review the research progress of fertility protection in patients with gynecological malignant tumors, in order to provide reference for clinical experience.

目的 阑尾黏液性肿瘤发病率极低,常导致腹膜假粘液瘤,临床症状差异很大,容易误诊或漏诊。本个案报道着重分析了一例阑尾黏液性肿瘤伴巨大转移瘤患者在接受腹腔化疗后的病程,旨在为阑尾黏液性肿瘤的诊治提供有价值的临床经验和参考。方法 回顾性分析潍坊医学院附属医2023年5月份收治的1例阑尾黏液性肿瘤伴巨大腹膜假黏液瘤患者的临床资料,并结合文献对该病的临床特点、诊疗经过、治疗反应进行分析总结。结果 患者为58岁男性,因查体发现腹水1年余入院。腹部增强CT及MR均提示:肝硬化、门脉高压、腹水,大网膜明显增厚,边缘轻度强化。首次探查术后给予腹腔化疗和靶向治疗后出现肠梗阻且保守治疗无效,再次行腹腔肿瘤减灭术+肠粘连松解术后症状缓解。结论 对于腹腔巨大肿瘤时需要考虑到是否阑尾来源,对于低级别阑尾黏液性肿瘤出现腹膜转移后推荐性肿瘤细胞减灭术联合腹腔热灌注化疗术,不推荐全身或者腹腔内化疗或靶向治疗。

Objective To investigate the changes in choroidal blood flow density in the macular region after undergoing phacoemulsification combined with intraocular lens(IOL )implantation in patients with type 2 diabetes mellitus (T2DM), and analyze its correlation with postoperative visual prognosis and macular complications. Methods A retrospective study was conducted that a total of 84 T2DM patients (84 eyes) who underwent unilateral phacoemulsification combined with intraocular lens implantation in our hospital from October 2022 to October 2025 were included as the diabetic group. Based on the presence and stage of diabetic retinopathy (DR), the diabetic group was divided into non-diabetic retinopathy group (NDR group) and mild-to-moderate non-proliferative DR group (NPDR group). A control group of 78 patients (78 eyes) with no history of diabetes and undergoing the same surgery at the same time was selected. Preoperative, at 1 week, 1 month, and 3 months postoperatively measurements of choroidal capillary layer blood flow density in the macular region, best corrected visual acuity (BCVA), and central macular thickness (CMT) were compared between the two groups. Repeated measures analysis of variance (ANOVA), independent samples t-test, and Pearson correlation analysis were employed. Results At 1 week, 1 month, and 3 months postoperatively, blood flow density in the subcentral, pericentral, and overall macular regions decreased compared to preoperative levels in all groups, the decline was more pronounced in the diabetic group than the control group (P<0.0125 after adjustment for bias) and greater in the NPDR group than in the NDR group. The incidence of postoperative macular edema in the diabetic group was 14.29%, significantly higher than that in the control group (2.56%) (P=0.010). In the diabetic group, the magnitude of blood flow at 1 week postoperatively decline showed significant correlations with preoperative HbA1c levels (P=0.004), CMT thickness at 1 month postoperatively (P<0.001), and LogMAR BCVA at 3 months postoperatively (P=0.005). Conclusion Diabetes significantly exacerbates the reduction in choroidal blood flow in the macular region following cataract surgery, with this effect being more pronounced in patients with mild-to-moderate NPDR. Early postoperative choroidal blood flow decline was significantly correlated with increased central macular thickness and worse postoperative visual acuity. Early postoperative choroidal blood flow monitoring holds significant clinical value for diabetic patients, particularly those complicated by DR.

Objective To observe the application effect of PDCA cycle-based pre-hospital emergency nursing care pathway in patients with acute myocardial infarction（AMI）. Methods 32 pre-hospital emergency nurses from our center were included as the study subjects. A retrospective analysis was conducted on 132 AMI patients who received resuscitation in our center between January 2023 and December 2023. Among them,60 patients treated before PDCA cycle implementation （January 2023 to June 2023） served as the control group,while 72 patients treated after implementation （July 2023 to December 2023） comprised the observation group. The control group received conventional nursing interventions,whereas the observation group received PDCA cycle interventions in addition to the conventional measures. Comparative analyses in the two groups were performed on prehospital emergency timeliness indicators （emergency response time,time to first electrocardiogram,prehospital resuscitation time,time to emergency department admission,resuscitation success rate,quality of life score,and satisfaction score）,and prehospital emergency care pathway quality scores （documentation quality score,key process score,and specialized emergency nursing score）. Results The emergency response time （5.66 ± 1.56 vs. 8.09 ± 3.05 min,P<0.001）,time to first electrocardiogram （8.12 ± 2.23 vs. 13.75 ± 1.56 min,P<0.001）,resuscitation time（29.72 ± 3.65 vs. 36.03 ± 9.21 min,P<0.001）,and time to emergency department admission （23.34 ± 8.12 vs. 39.67 ± 19.23 min,P<0.001） of the observation group were all significantly lower than those of the control group. The resuscitation success rate was significantly higher in the observation group（93.06% vs. 88.33%）. The observation group demonstrated significantly higher scores in both quality of life（assessed by SF-36）and satisfaction compared to the control group. Following PDCA implementation,the total nursing quality score increased from 71 ± 5.32 to 87 ± 4.15（P<0.01）. Conclusion The PDCA cycle-based pr-ehospital emergency nursing care pathway significantly enhances the timeliness of AMI pre-hospital emergency care,optimizes the nursing quality indicator system,and effectively improves patient expectations and clinical prognosis,and provide a theoretical basis for optimizing the prehospital emergency care model for AMI.

Objective To observe the clinical effect of Wenyang Huatan Zhike Decoction in the treatment of cough in patients with advanced lung cancer. Methods A total of 120 patients with advanced lung cancer and cough admitted from March 2022 to March 2025 were randomly divided into two groups by the envelope method. 60 patients in the conventional group were treated with phosphate Codeine tablets, while 60 patients in the experimental group were treated with Wenyang Huatan Zhixue Decoction. The total effective rate of Traditional Chinese Medicine(TCM) syndromes and adverse reactions of the two groups were statistically analyzed. The differences in TCM Syndrome Score, daytime and nighttime cough symptom scores, and Leicester Cough Scale (LCQ) scores were evaluated between the two groups. Results The total effective rate in the experimental group was higher than that in the conventional group, showing a statistically significant difference (P<0.05). The pre-treatment scores for the three primary symptoms, three secondary symptoms, and daytime/nighttime cough symptoms between the two groups were compared revealed no significant differences (P>0.05). Post-treatment scores for the three primary symptoms, three secondary symptoms, and daytime/nighttime cough symptoms decreased in both groups compared to pre-treatment levels, with the experimental group exhibiting lower scores across all these measures than the conventional group (P<0.05). Pre-treatment LCQ scores showed no significant difference between groups (P>0.05). Post-treatment LCQ total scores and scores across the social, psychological, and physical dimensions increased in both groups compared to pre-treatment levels. The trial group exhibited higher LCQ total scores and higher scores across all three dimensions than the conventional group (P<0.05). The incidence of adverse reactions in the experimental was comparable to that in the conventional group (P>0.05). Conclusion Wenyang Huatan Zhike Decoction can alleviate day and night cough symptoms, improve the quality of life, and enhance the therapeutic effect in patients with advanced lung cancer and cough.

Objective To observe the effects of vitrectomy combined with leizumab on visual acuity and serum endothelial growth factor (VEGF) levels in patients with proliferative diabetic retinopathy (PDR). Methods According to the random number table method, 86 patients with PDR admitted to hospital from October 2021 to March 2023 were divided into 2 groups with 43 cases each. The observation group was treated with vitrectomy combined with leizumab, and the control group was treated with vitrectomy. The visual acuity, iOP, serum index, macular fovea thickness and complications were compared between the two groups. Results After treatment, the visual acuity was improved and the IOP was decreased, and the improvement was more significant in the observation group (P < 0.05). Serum VEGF level decreased and PEDF level increased in both groups after treatment, and the improvement was more significant in observation group (P < 0.05). After treatment, the thickness of macular fovea decreased in both groups, and the improvement was more significant in the observation group (P < 0.05). Compared with the control group, the incidence of postoperative complications was lower in the observation group (P < 0.05). Conclusion Vitrectomy combined with leizumab can reduce VEGF level, macular fovea thickness and IOP level in PDR patients, improve visual acuity and reduce the incidence of postoperative complications.

Objective To explore the application effect of nursing intervention based on self-regulation theory in patients with gestational diabetes mellitus. Methods From March 2020 to October 2022, 100 pregnant women with gestational diabetes mellitus were included in the sample for consultation and treatment, and were divided into observation group and control group according to random number table method, with 50 patients in each group. The control group carried out general process nursing, and the observation group implemented nursing intervention mode based on self-regulation theory to observe the changes of blood sugar and pregnancy outcomes of pregnant women after intervention. Results After nursing intervention, the levels of fasting blood glucose (FPG), 2h postprandial blood glucose (2hPG) and glycosylated hemoglobin (HbA1c) in 2 groups were lower than before intervention, and the observation group was lower than the control group (P<0.05); The total satisfaction of observation group was higher than that of control group (96.00% vs 76.00%, P<0.05). The incidence of adverse pregnancy outcomes in observation group was lower than that in control group (6.00% vs 24.00%, P<0.05). After the intervention, the scores of all dimensions of self-efficacy in both groups were increased, and the increase range of observation group was greater than that of control group (P<0.05). After intervention, the quality of life scores of patients in both groups increased, and the increase range was greater in the observation group (P<0.05). Conclusion The nursing intervention mode based on self-regulation theory during the consultation of pregnant women with gestational diabetes can promote the stability of blood glucose level, prevent other complications during pregnancy, enhance the initiative of self-management and quality of life of pregnant women, and ultimately improve the pregnancy outcome.

Objective To explore the value of evaluating the levels of forkhead box protein M1 (FOXM1) and mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) in lung cancer tissues in assessing the short-term efficacy of postoperative adjuvant chemotherapy for lung cancer patients. Methods A retrospective selection was made of 108 lung cancer patients admitted to our hospital from August 2023 to August 2025. The protein expression levels of FOXM1 and MAP4K4 in lung cancer tissues were detected using immunohistochemistry. According to the expression of FOXM1, the 108 patients were divided into the FOXM1 high-expression group (n=44) and the FOXM1 low-expression group (n=64); according to the expression of MAP4K4, the 108 patients were divided into the MAP4K4 high-expression group (n=50) and the MAP4K4 low-expression group (n=58). The clinical characteristics and short-term effects among patients in the FOXM1 high-expression group and the FOXM1 low-expression group were compared, as well as those in the MAP4K4 high-expression group and the MAP4K4 low-expression group. Results In the FOXM1 highly expressed group and the MAP4K4 high-expression group, the proportions of poorly differentiated, lymph node metastasis, and patients with TNM stage Ⅲ-Ⅳ were higher (P<0.05). The ORR of the FOXM1 high-expression group and the MAP4K4 high-expression group was lower than that of the FOXM1 low-expression group and the MAP4K4 low-expression group respectively (P<0.05). Through ROC analysis, the area under the curve for the individual and combined prediction of short-term efficacy of postoperative adjuvant chemotherapy in lung cancer patients by FOXM1 and MAP4K4 was 0.741, 0.767, and 0.906, with sensitivities of 0.720, 0.760, and 0.820, and specificities of 0.759, 0.793, and 0.879. Conclusion High expression of FOXM1 and MAP4K4 is associated with a more aggressive malignancy of lung cancer and a poorer short-term efficacy of postoperative adjuvant chemotherapy, suggesting that they may serve as potential biomarkers for predicting chemotherapy resistance.