Objective To explore the diagnostic value of fibroblast growth factor 2 (FGF-2) and miR-215 in early gastric cancer, and to analyze their predictive value for recurrence after endoscopic submucosal dissection in patients. Method 90 early gastric cancer patients admitted to our hospital from January 2018 to January 2021 were selected as the study subjects and divided into an observation group. In addition, 90 volunteers who were confirmed as normal gastric mucosa through pathological biopsy during the same period were selected and divided into a control group. Compare the expression levels of FGF-2 and miR-215 between two groups of subjects, and establish a receiver operating characteristic (ROC) curve to analyze the diagnostic efficacy of FGF-2 and miR-215 in early gastric cancer. 90 patients with early gastric cancer were treated with endoscopic submucosal dissection. After surgery, patients were followed up and divided into two subgroups based on their recurrence status: the recurrent group (n=20) and the non recurrent group (n=70). The general clinical conditions of the two groups of patients were compared, and logistic regression analysis was used to analyze the predictive value of FGF-2 and miR-215 for recurrence in early gastric cancer patients after endoscopic submucosal dissection. Results The positive rate and expression level of FGF-2 in the gastric mucosa of the observation group were significantly higher than those of the control group, and the positive rate and expression level of miR-215 were significantly lower than those of the control group (P<0.05); The diagnostic efficiency of FGF-2 for early gastric cancer is significantly higher than that of miR-215 (P<0.05). The area under the curve of FGF-2 for early gastric cancer diagnosis is 0.852, with an optimal diagnostic threshold of 1.11, an area under the curve of miR-215 is 0.735, and an optimal diagnostic threshold of 0.86; There was a significant difference in infiltration depth, tissue differentiation, FGF-2 and miR-215 levels between the recurrent and non recurrent groups (P<0.05); The results of logistic regression analysis showed that FGF-2 and miR-215 were independent prognostic factors for gastric cancer patients (P<0.05). Conclusion FGF-2 and miR-215 have high diagnostic value for early gastric cancer, and an increase in FGF-2 levels and a decrease in miR-215 levels are independent predictive factors for recurrence of early gastric cancer after endoscopic submucosal dissection.

Objective To observe the effects of vitrectomy combined with leizumab on visual acuity and serum endothelial growth factor (VEGF) levels in patients with proliferative diabetic retinopathy (PDR). Methods According to the random number table method, 86 patients with PDR admitted to hospital from October 2021 to March 2023 were divided into 2 groups with 43 cases each. The observation group was treated with vitrectomy combined with leizumab, and the control group was treated with vitrectomy. The visual acuity, iOP, serum index, macular fovea thickness and complications were compared between the two groups. Results After treatment, the visual acuity was improved and the IOP was decreased, and the improvement was more significant in the observation group (P < 0.05). Serum VEGF level decreased and PEDF level increased in both groups after treatment, and the improvement was more significant in observation group (P < 0.05). After treatment, the thickness of macular fovea decreased in both groups, and the improvement was more significant in the observation group (P < 0.05). Compared with the control group, the incidence of postoperative complications was lower in the observation group (P < 0.05). Conclusion Vitrectomy combined with leizumab can reduce VEGF level, macular fovea thickness and IOP level in PDR patients, improve visual acuity and reduce the incidence of postoperative complications.

Surface electromyography is a technology used to detect muscle status, which is widely used in rehabilitation medicine, such as assessing muscle function status and evaluating rehabilitation efficacy, etc. This article reviews the application of surface electromyography in muscle function evaluation and curative effect evaluation of clinical diseases, in order to provide guidance for rehabilitation treatment.

Objective To explore the prevention and treatment of systemic adverse reactions in blood donation. Methods Collect data on 2194 cases of general-body response donation adverse reactions from January 2016 to January 2022, comb and analyze the causes of adverse reactions, and according to the time and place of adverse blood donation occurred (on-site) and the place of blood donation occurred (on-site) two subcategories (departure) of blood donation, using statistical methods to analyze the association between two types of adverse reactions and age, weight, first blood donation and gender. Results Among the 2194 cases of systemic reaction and adverse blood donation reactions, 2 146 cases occurred in the blood donation site, with an incidence rate of 1.11% (2146/192 691); 48 cases occurred after leaving the blood donation site, with an incidence rate of 0.02% (48/192 691). The difference between the two types of adverse reactions on the spot and leaving the field is statistically significant in the gender distribution (X²=88.79 P<0.01). The probability of adverse blood donation reaction in female blood donors is significantly higher than that of men; the age of adverse reactions on the spot is mainly concentrated in 18-29 years old; The age of blood donors is mainly concentrated in 30-39 years old and 40-49 years old, and the difference in age distribution is statistically significant (X²=81.80 P<0.05);the weight of blood donors with adverse reactions on the spot is mainly concentrated at 55-64kg, followed by 66-74kg; leaving the site with adverse reactions The weight of blood people is mainly concentrated in 75kg and above, and the difference in weight distribution is statistically significant (X²=18.33 P<0.05). Among the five types of reasons for induced adverse reactions of blood donation, psychological factors account for the highest proportion (72.79%). Conclusion The adverse reactions of systemic blood donation were related to gender, age, weight and whether the blood was donated for the first time. Psychological factors (excessive mental stress before blood donation) accounted for the highest proportion. More attention should be paid to female and young blood donors aged 18-29 years, blood donors weighing 55-64kg and over 75kg, and first-time blood donors. Attention should be paid to the notification of precautions before, during and after blood donation, effective communication with blood donors, improvement of puncture techniques, and improvement of donation environment. Stay for 30 minutes after blood donation and follow up after blood donation.

Objective To analyze the age, subtype distribution and multiple infection status of human papilloma virus (HPV) infection in women in Xiamen, and to provide theoretical basis for preventing HPV infection and reducing the incidence of cervical cancer. Methods The HPV gene was detected in the cervical exfoliated cells of 18573 female patients by PCR amplification and flow cytometry hybridization, and the distribution characteristics of HPV subtypes, single and multiple infections and HPV infection among different age groups were analyzed. Results There were 4926 high-risk HPV positive cases in 18573 patients, the total detection rate was 26.52%, and the single infection rate was 55.87%; The multiple infection rate was 44.13%. HPV52, HPV53, HPV58, HPV39 and HPV16 were the top five high-risk HPV infection rates, and HPV61, HPV44, HPV81, HPV43 and HPV55 were the top five low-risk HPV infection rates; HPV52 is the main type of single infection. 18573 female subjects, the minimum age is 17 years old and the maximum age is 87 years old. Comparison of HPV infection rates among women of different age groups: the infection rate of ≤ 20 years old group is the highest, the infection rate of>40-50 years old group is the lowest, and multiple infections are mainly in the age groups of ≤ 20 years old and>20-30 years old; In the distribution of HPV infection subtypes in different age groups, HPV52 type has the highest positive rate. Conclusion HPV infection in women in Xiamen is mainly single high-risk type, HPV52 and 16 types are common, and the distribution of HPV subtypes in different age groups is different, mainly HPV52 positive infection. We should strengthen the promotion of HPV-related health knowledge in this area, especially the reproductive health education of the group ≤ 20 years old, and actively promote the vaccination of HPV vaccine to improve the primary prevention of cervical cancer.

With the progress of surgical technology and the emergence of new arthroscopic equipment, minitrauma arthroscopic technique has been widely used in knee surgery. Compared with open surgery, arthroscopic knee surgery greatly reduces surgical trauma and postoperative pain. However, due to the injury of joint tissue caused by instruments and stimulation of joint cavity caused by washing fluid, different degrees of postoperative pain may still occur. At present, there are many methods for pain control after arthroscopic knee surgery, including periarticular local infiltration analgesia, peripheral nerve block, intravenous analgesia, intrathecal analgesia and multimodal analgesia. Selecting appropriate postoperative analgesia and promoting early postoperative functional exercise have become the focus of anesthesiologists. Therefore, this paper reviews the various analgesia methods after knee arthroscopy and their respective advantages and disadvantages.

目的 探讨循证护理结合运动康复对急性心肌梗死(AMI)患者经皮冠状动脉介入治疗(PCI)后心功能指标、运动能力及术后并发症发生率的影响。方法 回顾性分析2022年3月至2023年6月在山东第一医科大学附属省立医院接受PCI治疗的230例AMI患者的病历,并根据PCI后的护理方法将患者分为对照组(n=130)和研究组(n=100)。比较两组患者的心功能指标、6分钟步行距离、临床指标及术后并发症。结果 通过循证护理手段与运动康复的干预,研究组左心室射血分数明显高于对照组,B型钠尿肽原指数明显低于对照组(P<0.05)。在术后3和6个月,研究组的6分钟步行距离明显长于对照组(P<0.05)。术后3个月和6个月,研究组收缩压和舒张压、空腹的血糖、甘油三酯、总胆固醇与低密度脂蛋白均较对照组显著降低(P<0.05)。研究组心绞痛、心律失常、心力衰竭、低血压等并发症发生率低于对照组(P<0.05)。结论 循证护理结合运动康复可改善心功能和生理指标,降低术后并发症发生率,提高AMI患者PCI术后的生活质量。

Objective To explore the application effect of nursing intervention based on self-regulation theory in patients with gestational diabetes mellitus. Methods From March 2020 to October 2022, 100 pregnant women with gestational diabetes mellitus were included in the sample for consultation and treatment, and were divided into observation group and control group according to random number table method, with 50 patients in each group. The control group carried out general process nursing, and the observation group implemented nursing intervention mode based on self-regulation theory to observe the changes of blood sugar and pregnancy outcomes of pregnant women after intervention. Results After nursing intervention, the levels of fasting blood glucose (FPG), 2h postprandial blood glucose (2hPG) and glycosylated hemoglobin (HbA1c) in 2 groups were lower than before intervention, and the observation group was lower than the control group (P<0.05); The total satisfaction of observation group was higher than that of control group (96.00% vs 76.00%, P<0.05). The incidence of adverse pregnancy outcomes in observation group was lower than that in control group (6.00% vs 24.00%, P<0.05). After the intervention, the scores of all dimensions of self-efficacy in both groups were increased, and the increase range of observation group was greater than that of control group (P<0.05). After intervention, the quality of life scores of patients in both groups increased, and the increase range was greater in the observation group (P<0.05). Conclusion The nursing intervention mode based on self-regulation theory during the consultation of pregnant women with gestational diabetes can promote the stability of blood glucose level, prevent other complications during pregnancy, enhance the initiative of self-management and quality of life of pregnant women, and ultimately improve the pregnancy outcome.

This article discusses the application of artificial intelligence in elderly care, focusing on robot care, health monitoring, and cognitive training. Robot care can provide elderly people with 24/7 care and monitoring, including vital signs monitoring, household services, and social support. In terms of health monitoring, AI technology can remotely monitor the health status of elderly people through devices such as smart bracelets and provide better medical and health care services. In addition, the application of smart home devices also provides more convenient means of health monitoring for the elderly. In terms of cognitive training and treatment, AI can help elderly people improve their cognitive abilities and quality of life through technologies such as virtual reality. These applications bring many innovative solutions to elderly care, and their potential impact on the health and quality of life of the elderly is worth studying and exploring. In conclusion, the application of artificial intelligence in elderly care is a very promising direction for technological development, and we have reason to believe that in the future, it will provide better care and services for the elderly.

Objective To evaluate the value of TEG combined with D-dimer (D-D) in predicting the severity of ischemic cerebrovascular disease. Methods A total of 60 patients with ischemic cerebrovascular disease admitted to our hospital from July 2022 to June 2023 were selected and divided into severe group (13 cases), moderate group (21 cases) and mild group (26 cases) according to Glasgow Coma Score (GCS). TEG index and D-D test results of each group were compared, and the correlation between TEG index and GCS score was analyzed. Multivariate Logistic regression analysis was conducted to analyze the independent risk factors affecting the severity of ischemic cerebrovascular disease. ROC was used to analyze the value of TEG index combined with D-D test in evaluating the severity of ischemic cerebrovascular disease. Results The K, MA, R, α Angle, D-D values and GCS scores in severe group were higher than those in moderate group and mild group, and the test values and GCS scores in moderate group were higher than those in mild group (P<0.05). K and R values were negatively correlated with GCS score (P<0.05), while MA, α Angle and D-D values were positively correlated with GCS score (P<0.05). K and R prolongation were protective factors, while MA prolongation, α Angle increase and D-D increase were high risk factors (P<0.05). The AUC of TEG index combined with D-D test to evaluate the severity of ischemic cerebrovascular disease was 0.921, and the sensitivity was 92.30%, both higher than that of single test (P<0.05). Conclusion TEG index and D-D level are closely related to the severity of ischemic cerebrovascular disease. Combined detection can improve the accuracy of assessment.

Objective To explore the efficacy and safety of Liraglutide in the treatment of elderly overweight obese impaired glucose tolerance (IGT) arteriosclerosis. Methods From October 2019 to March 2020, 60 elderly IGT patients with overweight/obesity were recruited and randomly divided into control group (n=30) and observation group (n=30). The patients in the control group were treated with lifestyle intervention, while those in the observation group were treated with Liraglutide injection 1.2 mg daily on the basis of the control group. The treatment course was 6 months in both groups. The levels of blood glucose, blood lipid, carotid intima-media thickness (IMT) and inflammatory factors were measured before and after treatment. The incidence of adverse events during the study period was observed. Results Compared with the control group, body mass index, waist circumference (WC), hip circumference, fasting blood glucose, fasting insulin (FINS), glycated hemoglobin, 2-hour postprandial blood glucose, 2-hour postprandial insulin, total cholesterol, low-density lipoprotein (LDL), IMT, white blood cells, tumor necrosis factor (TNF-α), C-reactive protein and interleukin-6 (IL-6) were significantly different before and after treatment in the observation group (P＜0.05). Age, WC, FINS, LDL, TNF-α and IL-6 were independent risk factors for arteriosclerosis. There was no significant difference in the incidence of adverse events between the two groups during the study period (P=0.184). Conclusions Liraglutide can delay the development of atherosclerosis in overweight and obese elderly IGT patients, improve the inflammatory state and intimal function, and have small side effects.

目的 探究代谢综合征(MS)和老年良性前列腺增生(BPH)之间的关联性。方法 选取本院2019年1月-2021年12月收治的185例老年BPH患者作为研究对象,根据是否合并MS,分为两组,BPH合并MS设为观察组,BPH未合并MS设为对照组,其中观察组45例,对照组140例,分析比较两组患者年龄、血压、体质量指数(BMI)、空腹血糖(FPG)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、国际前列腺症状评分(IPSS)、最大尿流率(Qmax)、前列腺特异性抗原(PSA)、前列腺体积(PV)等指标,并采用多因素Logistic回归分析模型筛选出BPH发生的危险因素。结果 观察组患者的BMI、血压、FPC、TG、TC、LDL-C均高于对照组,HDL-C低于对照组,且差异均具有统计学意义(均P＜0.05);观察组患者的IPSS评分、PV均高于对照组,Qmax低于对照组,差异均具有统计学意义(均P＜0.05);Logistic回归分析结果显示,BMI、高血压、高FPC、高TG、高LDL-C均是BPH发生的独立危险因素,其OR分别为1.841 (95%CI:1.051~2.501)、1.785(95%C:1.612~2.623)、1.683(95%CI:1.011~3.890)、1.897(95%CI:1.581~2.964)、1.358(95%CI:1.244~3.015)。结论 MS及其组分与BPH的发生发展具有相关性。

目的 探讨外周血和脑脊液miR-146a和miR-146b表达在儿童抗NMDAR脑炎诊疗中的临床意义。方法 选取30例确诊为NMDAR脑炎儿童作为研究对象,随机将其分为观察组和对照组,每组各15例,对照组给予糖皮质激素和免疫球蛋白治疗,观察组联合利妥昔单抗治疗。于患儿入院诊断时和稳定康复出院前采集静脉血和脑脊液标本,采用PCR检测miR-146a和miR-146b的相对表达量。结果 两组患儿临床资料比较差异无统计学意义,P＞0.05;入院时两组患儿外周血和脑脊液miR-146a表达差异无统计学意义,P＞0.05;出院前观察组患儿外周血和脑脊液miR-146a表达较低,P＜0.05;入院时两组患儿外周血和脑脊液miR-146b表达差异无统计学意义,P＞0.05;出院前观察组患儿外周血和脑脊液miR-146b表达较低,P＜0.05;观察组疗效较对照组较好,P＜0.05。结论 miR-146a和miR-146b对诊断儿童抗NMDAR脑炎有重要临床意义。

Objective To analyze the changes in high-resolution CT (HRCT) scores, interleukin-34 (IL-34), blood cell sedimentation rate (ESR) levels, and prognostic value of active pulmonary tuberculosis after anti-tuberculosis treatment. Method 80 patients with active pulmonary tuberculosis admitted to our hospital from May 2019 to May 2023 were selected as the research subjects, all of whom underwent anti-tuberculosis treatment. The prognostic effects were analyzed, and the changes in HRCT scores, IL-34, and ESR levels before treatment were compared among patients with different prognosis. The prognostic value of the combination of HRCT scores, IL-34, and ESR levels was analyzed, as well as the risk of poor prognosis at different levels. Results Among the 80 active pulmonary tuberculosis patients, 59 had a good prognosis after anti tuberculosis treatment, and 21 had a poor prognosis; The HRCT score, IL-34, and ESR levels of patients with good prognosis were significantly lower than those with poor prognosis (P<0.05); The receiver operating characteristic (ROC) curve shows that the area under the curve (AUC) value of HRCT score, serum IL-34, and ESR levels combined to predict poor prognosis in active pulmonary tuberculosis patients is 0.846 (95% CI: 0.809-0.884), with the best sensitivity and specificity being 85.71% and 89.83%, respectively; The risk of poor prognosis in patients with active pulmonary tuberculosis with high HRCT scores, IL-34, and ESR levels is 4.167 times, 5.943 times, and 11.988 times higher than in patients with low levels (P<0.05). Conclusion The combination of HRCT score, IL-34, and ESR levels can effectively predict the prognosis of active pulmonary tuberculosis patients, and can be used as a clinical early prognostic indicator.

Thrombocytopenia related to tumor treatment can lead to bleeding, blood transfusion, program adjustment, delayed treatment, interruption and other adverse consequences, which seriously affects the anti-tumor efficacy and disease outcome. There are a variety of risk factors, involving local treatment factors, systemic treatment factors and patients' own factors. Appropriate adjustment of the treatment plan for patients with multiple risk factors may reduce the incidence and severity of thrombocytopenia caused by tumor treatment, so as to ensure the continuity of tumor treatment, improve the efficacy and extend it. Always survive. The author reviews the research progress of various risk factors related to thrombocytopenia related to tumor treatment, in order to help comprehensive clinical evaluation and provide reference for screening the treatment plan that is most conducive to patients.

Objective Observe the efficacy and safety of pirfenidone after pulmonary rehabilitation treatment in patients with CPEF. Methods This article is a prospective study, with cases included from January 2020 to May 2023. The study subjects were 80 patients with CPEF. The enrolled patients were randomly divided into a conventional group (40 cases) and an experimental group (40 cases) using computer randomization. The conventional group received routine lung rehabilitation treatment, while the experimental group received combination therapy with pirfenidone. The inflammatory cytokines, pulmonary fibrosis progression, pulmonary arterial blood gas indicators, and lung function improvement of the two groups of patients were compared, And medication safety. Results Before treatment, the inflammatory indicators of the two groups of patients were similar (P>0.05); After treatment, the TGF of the experimental group-β 1. MMP-9, TNF-α The levels of (125.35±20.61) ng/L, (30.41±5.16) ng/ml, and (3.36±0.27) ng/L were lower than those of the conventional group [(140.33±20.36) ng/L, (33.49±5.33) ng/ml, and (4.41±1.26) ng/L] (P<0.05). Before treatment, the progression of pulmonary fibrosis in both groups of patients was similar (P>0.05); After treatment, the ICAM-1, HA, and Ashcroft scores of the experimental group were (105.44±20.13) pg/ml, (25.44±5.17) ng/ml, and (3.46 ±0.25) points, respectively, which were lower than those of the conventional group [(120.36±20.14) pg/ml, (28.66±5.34) ng/ml, and (4.77±1.14) points] (P<0.05). Before treatment, the pulmonary arterial blood gas indicators of the two groups of patients were similar (P>0.05); After treatment, the PaO2 of the experimental group was (85.25±10.31) mmHg, which was higher than that of the conventional group (80.33±10.22) mmHg; PaCO₂ was (40.35±10.27) mmHg, lower than the conventional group (45.77±10.34) mmHg (P<0.05). Before treatment, the lung function of the two groups of patients was similar (P>0.05); After treatment, the FEV1, FVC, and PEF of the experimental group were (60.24±10.11)%, (2.54±0.26) L, and (488.75±50.61) L/min, respectively, which were higher than those of the conventional group [(54.41±10.23)%, (2.03±0.43) L, and (440.24±50.13) L/min] (P<0.05). Under different treatment regimens, the incidence of drug-related side effects in the experimental group was 15.00% (6/40), which was similar to 10.00% (4/40) in the conventional group (P>0.05). Conclusion Pifenidone can inhibit inflammatory factors and pulmonary fibrosis progression in CPEF patients, and has a positive effect on improving their pulmonary arterial blood gas indicators and promoting pulmonary function recovery; The combined use of this drug did not significantly increase the risk of drug-related side effects, and its safety was relatively high.

Subarachnoid hemorrhage (SAH) is a cerebrovascular disease with a high mortality and disability rate. Its pathological mechanism is complex, and clinicalresearch faces challenges such as insufficient stability and low survival rate of animal models. This consensus systematically summarizes the limitations of traditional SAH animal models and proposes optimized modeling techniques, significantly improve model stability and reduce the mortality rate of experimental animals. At the same time, a multi-modal intracranial monitoring system is constructed by combining both multi-channel flexible sensors and 3D bioprinted scaffolds, achieving real-time dynamic monitoring of intracranial pressure, cerebral oxygen partial pressure, and brain electrical activity, promoting the regeneration and repair of cranial bone defects. The application of the new system provides a highly reliable platform for the analysis of SAH pathological mechanisms, the evaluation of new therapies, and the development of brain-computer interfaces. It is expected to promote the clinical transformation of brain-computer interface research results.

Objective To explore the influence of empathic nursing combined with psychological suggestion on negative emotions and treatment compliance in infertility patients with endometriosis. Methods 80 infertility patients with endometriosis treated in our hospital from January 2020 to January 2023 were selected as research subjects, and 40 cases in each group were randomized. The control group received routine nursing intervention, and the study group received empathic nursing combined with psychological suggestion nursing intervention on the basis of the control group to compare relevant indicators. Results The total compliance rate in the study group was higher than that in the control group (P<0.05). After the two groups received nursing intervention, HAMD, HAMA and other negative emotion scores showed decline, and the observation group was lower than the control group (P<0.05). After receiving nursing intervention, life quality scores of both groups were increased, and the observation group was higher than the control group (P<0.05). Conclusion Infertility patients with endometriosis receive empathy nursing combined with psychological suggestion nursing intervention to improve medication compliance, improve negative emotions, and improve the quality of life.

Objective To explore the effect of WeChat remote guidance and rehabilitation nursing for patients with cardiac cancer after interventional surgery, and evaluate the impact on patients' self health compliance and negative emotions. Methods 80 patients with cardiac cancer after interventional surgery were divided into two groups, randomly divided into experimental group and control group, with 40 patients in each group. The experimental group received WeChat remote guidance and rehabilitation care, while the control group received routine care to compare patients' self care compliance and negative emotions. The study period was from September 2020 to September 2022. Results The scores of self health care compliance in the experimental group in terms of medication, diet, exercise, and reexamination were higher than those in the control group, with a significant difference (P<0.05); There was no statistically significant difference in HAMD and HAMA scores between the two groups before treatment (P>0.05). After treatment, the HAMD and HAMA scores of the two groups decreased, and the range of patients in the experimental group was greater, with a statistically significant difference (P<0.05); The nursing satisfaction of patients in the experimental group was 97.50%, while the nursing satisfaction of patients in the control group was 85.00%. The difference between the groups was statistically significant (P<0.05). Conclusion The effect of WeChat remote guidance and rehabilitation nursing for patients with cardiac cancer after interventional surgery is significant, which can promote patients' self health compliance and alleviate negative emotions, and can be promoted.

Objective To explore the effect of stereotactic Minimally invasive procedure for glioma. Methods 102 patients with glioblastoma in our hospital from January 2021 to April 2021 were selected for the study, Randomized number table was used to divide 51 patients into the reference group and the study group, each of which was treated with routine Craniotomy in the reference group and stereotactic Minimally invasive procedure in the study group The clinical efficacy, Neuropeptide, immune cells, ability of daily living (ADL) score and NIHSS score of the two groups were observed. Results The total effective rate of patients in the study group was 96.08%, higher than 80.39% in the reference group, with a significant difference (P<0.05). After 6 months of surgery, patients in the study group β-EP, AVP, Th1, Th17 were higher than the reference group, while Th2 was lower than the reference group, with significant differences (P<0.05). After 6 months of surgery, the ADL of the study group patients was higher than that of the reference group, and the NIHSS was lower than that of the reference group, with a significant difference (P<0.05). After 12 months of follow-up, the survival rate of patients in the study group was higher than that in the reference group, while the recurrence rate and metastasis rate were lower than those in the reference group, with significant differences (P<0.05). Conclusion Stereotactic Minimally invasive procedure for glioma can improve the clinical efficacy, promote the recovery of neural function and immune function, improve the ability of daily living, reduce the recurrence rate and metastasis rate, which is superior to conventional Craniotomy, and has the value of popularization.