Objective To explore the efficacy of low-dose azithromycin combined with Xinbicolol in the treatment of stable bronchiectasis. Methods 80 patients with stable bronchiectasis admitted to our hospital from October 2022 to March 2024 were randomly divided into two groups, with 40 cases in each group. Group A was treated with low-dose azithromycin combined with Xinbiguobao, while Group B was treated with Xinbiguobao. Compare two groups of inflammatory response, blood gas analysis indicators, and lung function indicators. Results After three courses of treatment, the levels of interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs CRP), and arterial partial pressure of carbon dioxide (PaCO₂) decreased in both groups, with Group A being lower than Group B; The ratio of arterial partial pressure of oxygen (PaO₂) and forced expiratory volume at 1 second (FEV1) to forced vital capacity (FVC), as well as the percentage of FEV1 to expected value (FEV1% pred), increased in both groups. Group A was higher than Group B (P<0.05). Conclusion The combination of low-dose azithromycin and Xin Bi Ke Du Bao can alleviate the inflammatory response in patients with stable bronchiectasis, improve their blood gas analysis indicators and lung function.

Subarachnoid hemorrhage (SAH) is a cerebrovascular disease with a high mortality and disability rate. Its pathological mechanism is complex, and clinicalresearch faces challenges such as insufficient stability and low survival rate of animal models. This consensus systematically summarizes the limitations of traditional SAH animal models and proposes optimized modeling techniques, significantly improve model stability and reduce the mortality rate of experimental animals. At the same time, a multi-modal intracranial monitoring system is constructed by combining both multi-channel flexible sensors and 3D bioprinted scaffolds, achieving real-time dynamic monitoring of intracranial pressure, cerebral oxygen partial pressure, and brain electrical activity, promoting the regeneration and repair of cranial bone defects. The application of the new system provides a highly reliable platform for the analysis of SAH pathological mechanisms, the evaluation of new therapies, and the development of brain-computer interfaces. It is expected to promote the clinical transformation of brain-computer interface research results.

Objective To explore the correlation between sub atherosclerosis and glycosylated hemoglobin variation index (HGI) in patients with type 2 diabetes mellitus (T2DM) and the influence of the latter on it. Methods 924 inpatients with T2DM admitted to the Endocrinology Department of Chengyang District People's Hospital in Qingdao from February 2018 to January 2021 were included, collected clinical data and tested various indicators. The subjects were divided into low HGI group, medium HGI group and high HGI group according to the three quantile method. The differences of the indicators were compared and the correlation between HGI and sub-atherosclerosis was analyzed. Results There were significant differences in SBP,HbA1c,total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C),fasting C-peptide, carotid intima-media thickness (CIMT) and the proportion of sub-atherosclerosis among the three groups (P<0.05). The fasting C-peptide level in the high HGI group was significantly lower than that in the low HGI group and the medium HGI group (P<0.05); HbA1c,UACR trend:high HGI group> medium HGI group> low HGI group, the difference was statistically significant (P<0.05); Compared with the low HGI group, the CIMT, sub-atherosclerosis ratio, HbA1c, TC,UACR, TG, LDL-C in the high HGI group increased significantly (P<0.05). Logistic regression analysis showed that elevated HGI was an independent risk factor for sub-atherosclerosis (OR=1.146, 95% CI: 1.013-1.426). Conclusion HGI in T2DM patients is related to sub-atherosclerosis, which may be helpful to prevent and treat the occurrence and development of CVD.

Objective To study the application effect of intra-articular injection of different doses of tranexamic acid in total knee arthroplasty, and its impact on blood loss and safety. Methods From March 2022 to March 2024, 120 patients who underwent total knee arthroplasty in our orthopedics department were selected for the study. They were divided into 4 groups using a lottery method, with 30 cases per group. Except for group I, which injected 50ml of physiological saline into the joint cavity, patients in groups II, III, and IV were all injected 50ml of tranexamic acid physiological saline into the joint cavity. Group II received a dose of 10mg/kg, group III received an injection dose of 20mg/kg, and group IV received an injection dose of 30mg/kg. The surgical related indicators, blood loss related indicators, coagulation function indicators, and incidence of thrombosis related complications were compared among the four groups. Results The surgical time, blood transfusion rate, average blood transfusion volume, FIB, D-D, and incidence of thrombosis related complications in Group I, Group II, Group III, and Group IV were compared with P>0.05, indicating good balance; However, the indexes of postoperative drainage flow, total blood loss, and hemoglobin decline value 72h after surgery in the four groups were gradually decreased, P<0.05. Conclusion The higher the dose of intra-articular injection of tranexamic acid in patients undergoing total knee arthroplasty, the more effective it is in reducing bleeding. Among them, 30mg/kg is the most effective, and it will not affect the patient's coagulation function or thrombosis related complications. The safety is guaranteed and is worthy of clinical adoption.

Objective Observing the effect of ear acupoint pressing on the treatment compliance and efficacy of pediatric allergic rhinitis. Methods This study is a prospective study, with 92 children with allergic rhinitis admitted to our hospital from January 2023 to December 2023. They were randomly divided into a conventional group (46 cases) and an ear acupoint group (46 cases) using computer randomization. The conventional group received conventional drug treatment, while the ear acupoint group received ear acupoint pressure bean adjuvant treatment. The treatment compliance, symptom score, inflammatory response, immune indicators of the two groups of children were compared. Results Under different treatment plans, the excellent and good treatment compliance rate of the ear acupuncture group was 93.48% (43/46) higher than that of the conventional group, which was 69.57% (32/46); The scores of symptoms such as nasal itching, nasal congestion, throat discomfort, and eye itching and redness in the ear acupoint group were (2.12±0.45) points, (2.25±0.36) points, and (2.18±0.29) points, respectively, lower than those in the conventional group [(3.49±0.77) points, (3.54±0.82) points, and (3.51±0.85) points]; The EOS and LYM of the ear acupoint group were (8.33±1.26)% and (40.23±10.45)%, respectively, which were lower than those of the conventional group [(10.44±2.35)% and (45.31±10.41) %]; The total IgE of the ear acupoint group (0.53±0.12) mg/L was lower than that of the conventional group (0.82±0.25) mg/L, while IgA and IgM were (2.49±0.37) g/L and (1.77±0.36) g/L, respectively, which were higher than those of the conventional group [(2.05±0.44) g/L and (1.28±0.65) g/L] (P<0.05). Conclusion Ear acupoint pressing beans can improve the treatment compliance of children with allergic rhinitis, effectively improve clinical symptoms, and have a positive significance in promoting the recovery of inflammatory response and enhancing immune function in children.

Objective To analyze the clinical characteristics and molecular mechanism of a patient with Williams-Beuren syndrome, and to improve the understanding of this disease among cardiologists. Methods High-throughput whole-exome and chromosome copy number variation were used to examine the etiology of the patients. Conclusion The deletion of 25~27 adjacent genes in chromosome 7Q11.23 region is the pathogenic cause of WBS syndrome, leading to complex clinical manifestations such as cardiovascular and urinary malformations.

Objective To observe the effect of Jingluo Gua Sha combined with Reaobao on improving the nutritional status of patients with chronic heart failure (CHF). Methods 100 patients with CHF with anorexia admitted to hospital from October 2022 to April 2024 were divided into control group (50 cases) and observation group (50 cases) by random number table method. The control group was treated with routine intervention, and the observation group was treated with meridian and collateral-gua sha combined with traditional Chinese medicine Reai Bao intervention. The nutritional status, fatigue status,quality of life and adverse symptoms of the two groups were compared. Results After intervention, the levels of hemoglobin, prealbumin and total albumin in observation group were higher than those in control group, the difference was statistically significant (P<0.05). After intervention, the BFI score of the observation group was lower than that of the control group, and the WHOQOL-BREF score was higher than that of the control group, with statistical significance (P<0.05). There was no significant difference in adverse reactions between groups (P>0.05). Conclusion The intervention of meridian Gua Sha combined with Remai Bao can improve the nutritional status, reduce fatigue, and improve the quality of life in CHF patients with good safety.

Objective Observing the clinical effect of iodine phosphate injection combined blood perfusion in the treatment of organic phosphorus poisoning. Methods This study is a prospective study, with 96 patients with organic phosphorus poisoning admitted to our hospital from January 2022 to December 2023. They were randomly divided into a drug group (48 cases) and a combination group (48 cases) using a computer randomization method. The drug group received blood perfusion surgery, while the combination group received iodine phosphate injection combined blood perfusion surgery. The CHE activity, symptom relief, inflammatory indicators, organ damage, and prognosis of the two groups of patients were compared. Results Under different treatment regimens, the CHE activity levels in the combination group after 24 hours, 48 hours, and 72 hours of treatment were (68.33±10.25)%, (75.29±10.43)%, and (85.36±10.24)%, higher than he drug group [(63.29±10.44)%, (70.32±10.34)%, and (80.29±10.47)%] (t=2.387,2.345,2.399; P<0.05); the central nervous system symptoms, muscarinic like symptoms, nicotinic like symptoms, respiratory system symptoms disappearance time, and hospital stay in the combination group were (4.23±1.25) h, (0.55±0.14) h, and (1.34±1.25) h, (0.85±0.19) h, and (5.75±1.32) d,lower than those in the drug group [(5.18±1.44) h, (0.83±0.21) h, (1.81±0.45) h, (1.21±0.51) h, (6.61±1.75) d] (t=3.452,7.686,6.205,4.583,2.718; P<0.05); CRP, PCT and IL-6 in the combination group were (5.32±1.24) mg/L, (0.52±0.13) μg/L, and (140.23±20.22) pg/ml,lower than the drug group [(6.21±1.49) mg/L, (0.88±0.21) μg/L, (155.39±20.45) pg/ml] (t=3.287,10.099,3.652; P<0.05); LDH, AST, and SCr in the combination group were (230.35±20.46) U/L, (38.44±5.28) U/L, and (160.25±20.33) μmol/L, lower than the drug group [(245.22±20.33) μmol/L, respectively 32) U/L, (41.35±5.36) U/L, (175.33±20.41) μmol/L [t=3.573,2.670,3.627; P<0.05]; the incidence of adverse prognosis in the combination group was 4.17% (2/48) lower than the drug group 20.83% (10/48) (x²=6.095; P<0.05). Conclusion Iodine phosphate injection combined blood perfusion can effectively reduce CHE activity in patients with organic phosphorus poisoning, promote symptom recovery, alleviate inflammatory reactions, organ damage, and improve prognosis.

The Tumor Necrosis Factor Alpha-Induced Protein 8 (TNFAIP8/TIPE) family is a recently discovered group of proteins that are closely associated with immune modulation and tumor growth. This family is currently the only known transporter of lipid second messengers, specifically phosphatidylinositol bisphosphate (PIP2) and phosphatidylinositol trisphosphate (PIP3). It comprises four members: TNFAIP8/TIPE, TNFAIP8L1/TIPE1, TNFAIP8L2/TIPE2, and TNFAIP8L3/TIPE3. Previous studies have demonstrated that proteins within this family can act as regulatory factors, playing significant roles in tumorigenesis, inflammation, and cell death. Moreover, an increasing body of evidence indicates that these family proteins also participate in immune regulation and serve as second messengers in the process of autophagy. This review aims to summarize the recent advances in the understanding of the roles of the TIPE family proteins in tumor progression and inflammatory diseases.

目的 探讨PCDH19簇集性癫痫患儿的临床特征及其基因检测分析,以提高临床医师对该病的早期认识。方法 收集2例婴幼儿起病的PCDH19簇集性癫痫患儿的临床资料、基因测序结果进行回顾性分析及随访,并复习相关文献。结果 2例患儿均为女童,起病年龄分别为7月龄、19月龄。癫痫发作形式以局灶性发作、GTCS发作为主,均具有丛集性发作的特点,发作频率10余次/d,持续1-2分钟/次,1次病程持续8-10d不等,均伴热敏感性。2例基因变异均为PCDH19杂合突变,其中1例突变位于1号外显子,含有c.1019A>T(p.Asn340Ile)错义突变,1例含有大片段缺失(PCDH19全基因缺失),均为新生突变,父母均为野生型。治疗1例给予丙戊酸钠、左乙拉西坦、氯硝西泮联合维持治疗,1例给予丙戊酸钠单药维持治疗,均得到有效控制,2例患儿急性发作期均使用咪达唑仑静脉泵入治疗,有效改善了丛集性发作。结论 婴幼儿起病以热敏感性和丛集性发作为特点的癫痫,需警惕PCDH19簇集性癫痫综合征,应尽早行基因检测。

Objective To investigate the effects of Symbicor Turbot combined with ipratropium bromide aerosol inhalation on inflammatory factors and lung function in patients with chronic obstructive pulmonary disease (COPD). Methods A total of 95 COPD patients admitted to the hospital from January 2023 to January 2024 were divided into control group (48 cases) and treatment group (47 cases) by drawing lots. The control group was given atomized inhalation of ipratropium bromide, the treatment group was treated with Cymbicort Dupro combined with ipratropium bromide nebulized inhalation therapy. The therapeutic effect, inflammatory factor levels [C-reactive protein (CRP), procalcitonin (PCT), interleukin-6 (IL-6)], blood gas indexes [arterial partial pressure of carbon dioxide (PaCO₂), arterial partial pressure of oxygen (PaO₂)], pulmonary function indexes [forced vital capacity (FVC), peak expiratory flow rate (PEF) and 1s usage were compared between the two groups Force expiratory volume (FEV1)] and adverse reactions. Results The total effective rate of the treatment group (93.62%) was higher than that of the control group (75.00%), the difference was statistically significant (P<0.05). After two weeks of treatment, The levels of CRP (10.51±2.35) mg/L, PCT (0.10±0.02) ng/Lng/ml, IL-6 (112.25±16.35), PaCO₂ (38.65±3.14) mmHg in the treatment group were higher than those in the control group (15.24±3.42) mg/L, (0.16±0.05) ) ng/ml, (130.24±18.41) ng/L, (44.58±3.60) mmHg low, The levels of PaO₂ (80.24±6.85) mmHg, FVC (3.11±0.48) L, PEF (3.22±0.81) L/s and FEV1 (2.62±0.48) L/s were higher than those of the control group (72.54±6.33) mmHg, (2.89±0.40) L and (2.81±0.74) L/s s and (2.31±0.41) L were high, and the difference was statistically significant (P<0.05). There was no significant difference in adverse reactions between the treatment group (14.89%) and the control group (10.42%) (P>0.05). Conclusion The treatment of COPD patients with Symbicor Turbot combined with ipratropium bromide is effective, which is beneficial to reduce inflammatory response, improve blood gas status, and enhance lung function, and has good safety.

Objective To observe the effects of laparoscopic radical gastrectomy on postoperative oxidative stress indexes and intestinal mucosal barrier indexes in patients with gastric cancer. Methods 86 patients with gastric cancer admitted to hospital from May 2022 to October 2023 were randomly divided into 2 groups with 43 cases in each group. The control group underwent traditional open radical gastrectomy, and the observation group underwent laparoscopic radical gastrectomy. The clinical operation indexes, postoperative oxidative stress indexes, intestinal mucosal barrier indexes and postoperative complications were compared between the two groups. Results The observation group was shorter than the control group in operation, first postoperative anal exhaust and hospital stay, and the amount of intraoperative bleeding was less (P < 0.05). One day after operation, MDA increased and SOD decreased in both groups, but MDA and SOD in observation group were lower and higher than those in control group (P < 0.05). One day after operation, ET, DAO and D-LAC were increased in both groups, but the observation group was lower than the control group (P <0.05). The incidence of postoperative complications was compared between the two groups (P > 0.05). Conclusion Laparoscopic radical gastrectomy has less oxidative stress damage on the body of gastric cancer patients, which is conducive to protecting intestinal mucosal barrier function, promoting postoperative gastrointestinal function recovery and shortening hospital stay.

Objective To systematically review the influencing factors of caring dependence in stroke patients, so as to provide a scientific basis for reducing caring dependence and improving the quality of life of stroke patients. Methods The literature on influencing factors of caring dependence in stroke patients from CNKI, Wanfang, VIP, CBM, CINAHL, Pubmed and other Chinese and foreign databases were searched from their inception to 30^th July 2023. Literature screening strictly followed the inclusion and exclusion criteria, and two researchers independently extracted data and evaluated the quality of the included literature. The research was analyzed by Review Manager 5.4 and Stata 14.0. Results A total of 9 studies involving 2362 subjects were included. The AHRQ quality assessment scores of the papers ranged from 6 to 9. The results of the meta-analysis showed that age, limb dysfunction, coexisting with other chronic diseases, degree of depression, cognitive dysfunction, and rehabilitation self-efficacy were the main influencing factors of caring dependence of stroke patients. Conclusions Caring dependence is common in stroke patients, but the level is inconsistent, and there are many influencing factors involved. High-risk groups should be identified as soon as possible and targeted nursing intervention should be carried out.

Objective To explore the superiority of CYP3A5*3 gene polymorphism detection in the treatment of idiopathic membranous nephropathy (IMN) with tacrolimus,and provide reference for personalized treatment of IMN patients. Methods 75 patients with IMN were included and divided into three groups based on CYP3A5*3genotype：AA,AG,and GG. All patients received tacrolimus treatment with an initial dose of 0. 05 mg/kg•d,twice daily,and the dose was adjusted based on blood drug concentration during the 6-month treatment period. The study simultaneously monitored the levels of urinary protein,plasma albumin,renal function indicators (urea nitrogen,serum creatinine),as well as the levels of inflammatory markers IL-6 and TNF-αin patients. Results After treatment,the total effective rates of AA,AG,and GG patients were 72%,88%,and 92%,respectively. The total effective rates of AG and GG patients were significantly higher than those of AA patients (P<0.05). After treatment,the 24-hour urinary protein,urea nitrogen,and serum creatinine levels of the three groups of patients significantly decreased compared to before treatment. Both AG and GG patients showed a significant decrease compared to AA patients (P<0.05). The plasma albumin,AST,and ALT levels of the three groups of patients significantly increased or decreased after treatment (P<0.05). The plasma albumin levels of AG and GG patients were significantly higher than those of AA patients (P<0.05),while the AST and ALT levels were significantly lower than those of AA patients (P<0.05). The levels of IL-6 and TNF - α in AG and GG patients were significantly reduced compared to before treatment,and were significantly lower than those in the AA group（P<0.05）. Conclusion CYP3A5*3 gene polymorphism detection can effectively guide the application of tacrolimus in IMN patients,optimize drug dosage,improve efficacy,reduce adverse reactions,and provide important reference for personalized treatment.

Objective To explore the impact of seamless management combined with procedural health education on the knowledge and complications related to peripheral venous catheterization (PICC) in patients with acute leukemia. Methods 62 patients with acute leukemia admitted to the Second Affiliated Hospital of Nanchang University from March 2021 to September 2023 were selected and randomLy divided into two groups of 31 each using a random number table. The control group received routine intervention,while the observation group implemented seamless management throughout the process combined with procedural health education. Compare the mastery of PICC replacement related knowledge,negative emotions,complications,and quality of life between two groups. Results The observation group had a higher mastery of PICC catheterization related knowledge and a lower incidence of complications compared to the control group (P<0.05);Compare the negative emotions and quality of life between the two groups before intervention (P>0.05);After intervention,the scores of the Self Rating Depression Scale (SDS) and Self Rating Anxiety Scale (SAS) in the observation group were lower than those in the control group,while the scores of each dimension in the WHO Quality of Life Inventory (WHOQOL-BREF) were higher than those in the control group (P<0.05). Conclusion The seamless management of the entire process combined with procedural health education can improve the mastery of PICC catheterization related knowledge in patients with acute leukemia,reduce negative emotions,minimize complications,and improve their quality of life.

Objective To construct the entry standards and job competency evaluation index system of online appointment nurse, providing reference for the selection and evaluation of online appointment nurse. Methods Based on the theory of competency iceberg, the evaluation index system was formulated by using the methods of literature research, group discussion, and Delphi expert inquiry. The weights of each index were determined by the analytic hierarchy process. Results Two rounds of expert inquiry were conducted, with positive coefficients of 100% for both rounds. The authority coefficients were 0.83 and 0.84, the consistency coefficients were 0.214 and 0.256, Finally a competency evaluation index system for online appointment nurse was constructed, including 4 entry standards, 4 first-level indicators, 12 second-level indicators, and 47 third-level indicators. Conclusion The construction of the entry standards and job competency evaluation index system for online appointment nurse is scientific and reliable, providing reference for the entry, training, and evaluation of internet-based nursing appointment in China.

Objective To explore the effect of cross theoretical model behavioral intervention strategies on the knowledge, beliefs, and practices of hospital infection prevention and control among interns. Methods Relevant literature and materials were consulted both domestically and internationally. A self-designed "Intern Hospital Infection Awareness Survey Form" was used to investigate the knowledge, attitudes, and behaviors of hospital infections among interns from 15 medical schools interning at a tertiary comprehensive hospital in Huizhou from 2023 to 2024. Behavioral intervention strategies based on cross theoretical models were implemented, and the intervention effects were compared in terms of intern hospital infection prevention and control knowledge survey scores, attitude survey scores, behavior change scores, and implementation of infection control measures before and after intervention. Results The total score of the intern's knowledge related to hospital infection prevention and control was (53.23±5.36) points, the total score of attitude was (18.26±2.48) points, and the total score of behavior was (8.23±1.45) points; After intervention, the hospital infection prevention and control knowledge, belief, and behavior scores of interns were significantly higher than before intervention (P<0.05); The implementation rate of infection control measures among interns after intervention was significantly higher than before intervention (P<0.05). Conclusion Behavioral intervention strategies based on cross theoretical models can enhance the awareness of hospital infection prevention and control among interns, improve their knowledge, beliefs, and behaviors, and reduce the occurrence of hospital infection events.

Objective Observing the effect of the Liyan acupuncture method based on syndrome differentiation and acupoint selection on improving the recovery of swallowing function after cerebral infarction. Methods This article will conduct a prospective, randomized controlled clinical trial on 100 patients with cerebral infarction admitted to the First People's Hospital of Nanyang City from January 2022 to December 2023. The enrolled patients were randomly divided into a control group and an acupuncture group using computer randomization, with 50 cases in each group. The conventional group received routine swallowing function training and feeding training, while the acupuncture group received throat benefiting acupuncture based on syndrome differentiation combined with routine rehabilitation training. The rehabilitation effects of the two groups of patients were compared. Results The maximum amplitude, average amplitude, and swallowing time of the submental muscle group during empty swallowing in the combined group were lower than those in the conventional group; The peak tongue pressure, average tongue pressure, and duration of tongue pressure were all higher than those in the control group; The SSA score and RSST score were lower than those of the control group; TP, ALB, and TRF were all higher than those in the control group (P<0.05). Conclusion The pharyngeal acupuncture method based on syndrome differentiation and acupoint selection can effectively improve the surface electromyographic value of the submandibular muscle group and tongue muscle strength in patients with cerebral infarction. It has a positive significance in promoting the recovery of swallowing function, improving the nutritional status of the body.

Sarcopenia is an age-related disease that brings numerous adverse consequences to patients and imposes an economic burden on society. The gut-muscle axis, serving as a bridge between intestinal flora and muscle, holds the potential for treating sarcopenia. However, its mechanism remains unclear, and the effect of intervention on sarcopenia is still far from ideal. Therefore, this paper reviews the correlation between the gut-muscle axis and sarcopenia, the involvement of the gut-muscle axis in the pathogenesis of sarcopenia, and the intervention of the gut-muscle axis on sarcopenia. The results demonstrate that intestinal flora can influence muscle quality and function through protein synthesis and decomposition, mitochondrial function, oxidative stress, insulin resistance, and chronic low-grade inflammation, among others. Moreover, the combination of exercise and drugs, particularly in combination with intestinal flora butyrate, can yield a better therapeutic outcome for sarcopenia.

Objective To analyze the prognostic value of TOAST typing in patients with acute ischemic stroke caused by HMCAS. Methods 184 patients with acute ischemic stroke (HMCAS positive) who underwent mechanical thrombectomy (MT) treatment in our hospital from December 2021 to December 2023 were selected as the study subjects. The TOAST classification of HMCAS acute ischemic stroke was determined based on preoperative and postoperative auxiliary examinations and grouped according to the TOAST classification. Compare the general information, clinical data, postoperative condition, NIHSS score, and mRS score of patients with different TOAST subtypes. Results There was no significant statistical difference in age, gender, and other aspects among patients with different TOAST subtypes (P>0.05). There was no statistically significant difference in the distribution of alcohol abuse, family history of stroke, and homocysteinemia among different TOAST subtypes (P>0.05); The distribution of smoking, hypertension, hyperlipidemia, diabetes, coronary heart disease and uric acid levels in different TOAST classifications was statistically different (P<0.05). The distribution of mTICI grading and symptomatic intracranial hemorrhage showed statistical differences among different TOAST subtypes (P<0.05). The number of patients in the SOE group was relatively small and further statistical analysis was not conducted; Compared with other TOAST subtypes, the CE group had significantly higher preoperative and 2-hour postoperative NIHSS scores, as well as 3-month postoperative mRS scores, and the differences were statistically significant (P<0.05); Compared with other TOAST subtypes, the SAA group had significantly lower preoperative and 2-hour postoperative NIHSS scores, as well as 3-month postoperative mRS scores, and the differences were statistically significant (P<0.05). Conclusion TOAST typing is helpful in evaluating the prognosis of mechanical thrombectomy (MT) treatment in patients with acute ischemic stroke (HMCAS positive).