Objective To explore the efficacy of low-dose azithromycin combined with Xinbicolol in the treatment of stable bronchiectasis. Methods 80 patients with stable bronchiectasis admitted to our hospital from October 2022 to March 2024 were randomly divided into two groups, with 40 cases in each group. Group A was treated with low-dose azithromycin combined with Xinbiguobao, while Group B was treated with Xinbiguobao. Compare two groups of inflammatory response, blood gas analysis indicators, and lung function indicators. Results After three courses of treatment, the levels of interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs CRP), and arterial partial pressure of carbon dioxide (PaCO₂) decreased in both groups, with Group A being lower than Group B; The ratio of arterial partial pressure of oxygen (PaO₂) and forced expiratory volume at 1 second (FEV1) to forced vital capacity (FVC), as well as the percentage of FEV1 to expected value (FEV1% pred), increased in both groups. Group A was higher than Group B (P<0.05). Conclusion The combination of low-dose azithromycin and Xin Bi Ke Du Bao can alleviate the inflammatory response in patients with stable bronchiectasis, improve their blood gas analysis indicators and lung function.

Objective To explore the correlation between sub atherosclerosis and glycosylated hemoglobin variation index (HGI) in patients with type 2 diabetes mellitus (T2DM) and the influence of the latter on it. Methods 924 inpatients with T2DM admitted to the Endocrinology Department of Chengyang District People's Hospital in Qingdao from February 2018 to January 2021 were included, collected clinical data and tested various indicators. The subjects were divided into low HGI group, medium HGI group and high HGI group according to the three quantile method. The differences of the indicators were compared and the correlation between HGI and sub-atherosclerosis was analyzed. Results There were significant differences in SBP,HbA1c,total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C),fasting C-peptide, carotid intima-media thickness (CIMT) and the proportion of sub-atherosclerosis among the three groups (P<0.05). The fasting C-peptide level in the high HGI group was significantly lower than that in the low HGI group and the medium HGI group (P<0.05); HbA1c,UACR trend:high HGI group> medium HGI group> low HGI group, the difference was statistically significant (P<0.05); Compared with the low HGI group, the CIMT, sub-atherosclerosis ratio, HbA1c, TC,UACR, TG, LDL-C in the high HGI group increased significantly (P<0.05). Logistic regression analysis showed that elevated HGI was an independent risk factor for sub-atherosclerosis (OR=1.146, 95% CI: 1.013-1.426). Conclusion HGI in T2DM patients is related to sub-atherosclerosis, which may be helpful to prevent and treat the occurrence and development of CVD.

Objective To study the application effect of intra-articular injection of different doses of tranexamic acid in total knee arthroplasty, and its impact on blood loss and safety. Methods From March 2022 to March 2024, 120 patients who underwent total knee arthroplasty in our orthopedics department were selected for the study. They were divided into 4 groups using a lottery method, with 30 cases per group. Except for group I, which injected 50ml of physiological saline into the joint cavity, patients in groups II, III, and IV were all injected 50ml of tranexamic acid physiological saline into the joint cavity. Group II received a dose of 10mg/kg, group III received an injection dose of 20mg/kg, and group IV received an injection dose of 30mg/kg. The surgical related indicators, blood loss related indicators, coagulation function indicators, and incidence of thrombosis related complications were compared among the four groups. Results The surgical time, blood transfusion rate, average blood transfusion volume, FIB, D-D, and incidence of thrombosis related complications in Group I, Group II, Group III, and Group IV were compared with P>0.05, indicating good balance; However, the indexes of postoperative drainage flow, total blood loss, and hemoglobin decline value 72h after surgery in the four groups were gradually decreased, P<0.05. Conclusion The higher the dose of intra-articular injection of tranexamic acid in patients undergoing total knee arthroplasty, the more effective it is in reducing bleeding. Among them, 30mg/kg is the most effective, and it will not affect the patient's coagulation function or thrombosis related complications. The safety is guaranteed and is worthy of clinical adoption.

Objective Observing the effect of ear acupoint pressing on the treatment compliance and efficacy of pediatric allergic rhinitis. Methods This study is a prospective study, with 92 children with allergic rhinitis admitted to our hospital from January 2023 to December 2023. They were randomly divided into a conventional group (46 cases) and an ear acupoint group (46 cases) using computer randomization. The conventional group received conventional drug treatment, while the ear acupoint group received ear acupoint pressure bean adjuvant treatment. The treatment compliance, symptom score, inflammatory response, immune indicators of the two groups of children were compared. Results Under different treatment plans, the excellent and good treatment compliance rate of the ear acupuncture group was 93.48% (43/46) higher than that of the conventional group, which was 69.57% (32/46); The scores of symptoms such as nasal itching, nasal congestion, throat discomfort, and eye itching and redness in the ear acupoint group were (2.12±0.45) points, (2.25±0.36) points, and (2.18±0.29) points, respectively, lower than those in the conventional group [(3.49±0.77) points, (3.54±0.82) points, and (3.51±0.85) points]; The EOS and LYM of the ear acupoint group were (8.33±1.26)% and (40.23±10.45)%, respectively, which were lower than those of the conventional group [(10.44±2.35)% and (45.31±10.41) %]; The total IgE of the ear acupoint group (0.53±0.12) mg/L was lower than that of the conventional group (0.82±0.25) mg/L, while IgA and IgM were (2.49±0.37) g/L and (1.77±0.36) g/L, respectively, which were higher than those of the conventional group [(2.05±0.44) g/L and (1.28±0.65) g/L] (P<0.05). Conclusion Ear acupoint pressing beans can improve the treatment compliance of children with allergic rhinitis, effectively improve clinical symptoms, and have a positive significance in promoting the recovery of inflammatory response and enhancing immune function in children.

Objective To analyze the clinical characteristics and molecular mechanism of a patient with Williams-Beuren syndrome, and to improve the understanding of this disease among cardiologists. Methods High-throughput whole-exome and chromosome copy number variation were used to examine the etiology of the patients. Conclusion The deletion of 25~27 adjacent genes in chromosome 7Q11.23 region is the pathogenic cause of WBS syndrome, leading to complex clinical manifestations such as cardiovascular and urinary malformations.

Subarachnoid hemorrhage (SAH) is a cerebrovascular disease with a high mortality and disability rate. Its pathological mechanism is complex, and clinicalresearch faces challenges such as insufficient stability and low survival rate of animal models. This consensus systematically summarizes the limitations of traditional SAH animal models and proposes optimized modeling techniques, significantly improve model stability and reduce the mortality rate of experimental animals. At the same time, a multi-modal intracranial monitoring system is constructed by combining both multi-channel flexible sensors and 3D bioprinted scaffolds, achieving real-time dynamic monitoring of intracranial pressure, cerebral oxygen partial pressure, and brain electrical activity, promoting the regeneration and repair of cranial bone defects. The application of the new system provides a highly reliable platform for the analysis of SAH pathological mechanisms, the evaluation of new therapies, and the development of brain-computer interfaces. It is expected to promote the clinical transformation of brain-computer interface research results.

Objective To observe the effect of Jingluo Gua Sha combined with Reaobao on improving the nutritional status of patients with chronic heart failure (CHF). Methods 100 patients with CHF with anorexia admitted to hospital from October 2022 to April 2024 were divided into control group (50 cases) and observation group (50 cases) by random number table method. The control group was treated with routine intervention, and the observation group was treated with meridian and collateral-gua sha combined with traditional Chinese medicine Reai Bao intervention. The nutritional status, fatigue status,quality of life and adverse symptoms of the two groups were compared. Results After intervention, the levels of hemoglobin, prealbumin and total albumin in observation group were higher than those in control group, the difference was statistically significant (P<0.05). After intervention, the BFI score of the observation group was lower than that of the control group, and the WHOQOL-BREF score was higher than that of the control group, with statistical significance (P<0.05). There was no significant difference in adverse reactions between groups (P>0.05). Conclusion The intervention of meridian Gua Sha combined with Remai Bao can improve the nutritional status, reduce fatigue, and improve the quality of life in CHF patients with good safety.

Objective Observing the clinical effect of iodine phosphate injection combined blood perfusion in the treatment of organic phosphorus poisoning. Methods This study is a prospective study, with 96 patients with organic phosphorus poisoning admitted to our hospital from January 2022 to December 2023. They were randomly divided into a drug group (48 cases) and a combination group (48 cases) using a computer randomization method. The drug group received blood perfusion surgery, while the combination group received iodine phosphate injection combined blood perfusion surgery. The CHE activity, symptom relief, inflammatory indicators, organ damage, and prognosis of the two groups of patients were compared. Results Under different treatment regimens, the CHE activity levels in the combination group after 24 hours, 48 hours, and 72 hours of treatment were (68.33±10.25)%, (75.29±10.43)%, and (85.36±10.24)%, higher than he drug group [(63.29±10.44)%, (70.32±10.34)%, and (80.29±10.47)%] (t=2.387,2.345,2.399; P<0.05); the central nervous system symptoms, muscarinic like symptoms, nicotinic like symptoms, respiratory system symptoms disappearance time, and hospital stay in the combination group were (4.23±1.25) h, (0.55±0.14) h, and (1.34±1.25) h, (0.85±0.19) h, and (5.75±1.32) d,lower than those in the drug group [(5.18±1.44) h, (0.83±0.21) h, (1.81±0.45) h, (1.21±0.51) h, (6.61±1.75) d] (t=3.452,7.686,6.205,4.583,2.718; P<0.05); CRP, PCT and IL-6 in the combination group were (5.32±1.24) mg/L, (0.52±0.13) μg/L, and (140.23±20.22) pg/ml,lower than the drug group [(6.21±1.49) mg/L, (0.88±0.21) μg/L, (155.39±20.45) pg/ml] (t=3.287,10.099,3.652; P<0.05); LDH, AST, and SCr in the combination group were (230.35±20.46) U/L, (38.44±5.28) U/L, and (160.25±20.33) μmol/L, lower than the drug group [(245.22±20.33) μmol/L, respectively 32) U/L, (41.35±5.36) U/L, (175.33±20.41) μmol/L [t=3.573,2.670,3.627; P<0.05]; the incidence of adverse prognosis in the combination group was 4.17% (2/48) lower than the drug group 20.83% (10/48) (x²=6.095; P<0.05). Conclusion Iodine phosphate injection combined blood perfusion can effectively reduce CHE activity in patients with organic phosphorus poisoning, promote symptom recovery, alleviate inflammatory reactions, organ damage, and improve prognosis.

The Tumor Necrosis Factor Alpha-Induced Protein 8 (TNFAIP8/TIPE) family is a recently discovered group of proteins that are closely associated with immune modulation and tumor growth. This family is currently the only known transporter of lipid second messengers, specifically phosphatidylinositol bisphosphate (PIP2) and phosphatidylinositol trisphosphate (PIP3). It comprises four members: TNFAIP8/TIPE, TNFAIP8L1/TIPE1, TNFAIP8L2/TIPE2, and TNFAIP8L3/TIPE3. Previous studies have demonstrated that proteins within this family can act as regulatory factors, playing significant roles in tumorigenesis, inflammation, and cell death. Moreover, an increasing body of evidence indicates that these family proteins also participate in immune regulation and serve as second messengers in the process of autophagy. This review aims to summarize the recent advances in the understanding of the roles of the TIPE family proteins in tumor progression and inflammatory diseases.

目的 探讨PCDH19簇集性癫痫患儿的临床特征及其基因检测分析,以提高临床医师对该病的早期认识。方法 收集2例婴幼儿起病的PCDH19簇集性癫痫患儿的临床资料、基因测序结果进行回顾性分析及随访,并复习相关文献。结果 2例患儿均为女童,起病年龄分别为7月龄、19月龄。癫痫发作形式以局灶性发作、GTCS发作为主,均具有丛集性发作的特点,发作频率10余次/d,持续1-2分钟/次,1次病程持续8-10d不等,均伴热敏感性。2例基因变异均为PCDH19杂合突变,其中1例突变位于1号外显子,含有c.1019A>T(p.Asn340Ile)错义突变,1例含有大片段缺失(PCDH19全基因缺失),均为新生突变,父母均为野生型。治疗1例给予丙戊酸钠、左乙拉西坦、氯硝西泮联合维持治疗,1例给予丙戊酸钠单药维持治疗,均得到有效控制,2例患儿急性发作期均使用咪达唑仑静脉泵入治疗,有效改善了丛集性发作。结论 婴幼儿起病以热敏感性和丛集性发作为特点的癫痫,需警惕PCDH19簇集性癫痫综合征,应尽早行基因检测。

Objective To investigate the effects of Symbicor Turbot combined with ipratropium bromide aerosol inhalation on inflammatory factors and lung function in patients with chronic obstructive pulmonary disease (COPD). Methods A total of 95 COPD patients admitted to the hospital from January 2023 to January 2024 were divided into control group (48 cases) and treatment group (47 cases) by drawing lots. The control group was given atomized inhalation of ipratropium bromide, the treatment group was treated with Cymbicort Dupro combined with ipratropium bromide nebulized inhalation therapy. The therapeutic effect, inflammatory factor levels [C-reactive protein (CRP), procalcitonin (PCT), interleukin-6 (IL-6)], blood gas indexes [arterial partial pressure of carbon dioxide (PaCO₂), arterial partial pressure of oxygen (PaO₂)], pulmonary function indexes [forced vital capacity (FVC), peak expiratory flow rate (PEF) and 1s usage were compared between the two groups Force expiratory volume (FEV1)] and adverse reactions. Results The total effective rate of the treatment group (93.62%) was higher than that of the control group (75.00%), the difference was statistically significant (P<0.05). After two weeks of treatment, The levels of CRP (10.51±2.35) mg/L, PCT (0.10±0.02) ng/Lng/ml, IL-6 (112.25±16.35), PaCO₂ (38.65±3.14) mmHg in the treatment group were higher than those in the control group (15.24±3.42) mg/L, (0.16±0.05) ) ng/ml, (130.24±18.41) ng/L, (44.58±3.60) mmHg low, The levels of PaO₂ (80.24±6.85) mmHg, FVC (3.11±0.48) L, PEF (3.22±0.81) L/s and FEV1 (2.62±0.48) L/s were higher than those of the control group (72.54±6.33) mmHg, (2.89±0.40) L and (2.81±0.74) L/s s and (2.31±0.41) L were high, and the difference was statistically significant (P<0.05). There was no significant difference in adverse reactions between the treatment group (14.89%) and the control group (10.42%) (P>0.05). Conclusion The treatment of COPD patients with Symbicor Turbot combined with ipratropium bromide is effective, which is beneficial to reduce inflammatory response, improve blood gas status, and enhance lung function, and has good safety.

Objective To explore the effect of cross theoretical model behavioral intervention strategies on the knowledge, beliefs, and practices of hospital infection prevention and control among interns. Methods Relevant literature and materials were consulted both domestically and internationally. A self-designed "Intern Hospital Infection Awareness Survey Form" was used to investigate the knowledge, attitudes, and behaviors of hospital infections among interns from 15 medical schools interning at a tertiary comprehensive hospital in Huizhou from 2023 to 2024. Behavioral intervention strategies based on cross theoretical models were implemented, and the intervention effects were compared in terms of intern hospital infection prevention and control knowledge survey scores, attitude survey scores, behavior change scores, and implementation of infection control measures before and after intervention. Results The total score of the intern's knowledge related to hospital infection prevention and control was (53.23±5.36) points, the total score of attitude was (18.26±2.48) points, and the total score of behavior was (8.23±1.45) points; After intervention, the hospital infection prevention and control knowledge, belief, and behavior scores of interns were significantly higher than before intervention (P<0.05); The implementation rate of infection control measures among interns after intervention was significantly higher than before intervention (P<0.05). Conclusion Behavioral intervention strategies based on cross theoretical models can enhance the awareness of hospital infection prevention and control among interns, improve their knowledge, beliefs, and behaviors, and reduce the occurrence of hospital infection events.

Objective Observing the effect of the Liyan acupuncture method based on syndrome differentiation and acupoint selection on improving the recovery of swallowing function after cerebral infarction. Methods This article will conduct a prospective, randomized controlled clinical trial on 100 patients with cerebral infarction admitted to the First People's Hospital of Nanyang City from January 2022 to December 2023. The enrolled patients were randomly divided into a control group and an acupuncture group using computer randomization, with 50 cases in each group. The conventional group received routine swallowing function training and feeding training, while the acupuncture group received throat benefiting acupuncture based on syndrome differentiation combined with routine rehabilitation training. The rehabilitation effects of the two groups of patients were compared. Results The maximum amplitude, average amplitude, and swallowing time of the submental muscle group during empty swallowing in the combined group were lower than those in the conventional group; The peak tongue pressure, average tongue pressure, and duration of tongue pressure were all higher than those in the control group; The SSA score and RSST score were lower than those of the control group; TP, ALB, and TRF were all higher than those in the control group (P<0.05). Conclusion The pharyngeal acupuncture method based on syndrome differentiation and acupoint selection can effectively improve the surface electromyographic value of the submandibular muscle group and tongue muscle strength in patients with cerebral infarction. It has a positive significance in promoting the recovery of swallowing function, improving the nutritional status of the body.

Objective To observe the effects of laparoscopic radical gastrectomy on postoperative oxidative stress indexes and intestinal mucosal barrier indexes in patients with gastric cancer. Methods 86 patients with gastric cancer admitted to hospital from May 2022 to October 2023 were randomly divided into 2 groups with 43 cases in each group. The control group underwent traditional open radical gastrectomy, and the observation group underwent laparoscopic radical gastrectomy. The clinical operation indexes, postoperative oxidative stress indexes, intestinal mucosal barrier indexes and postoperative complications were compared between the two groups. Results The observation group was shorter than the control group in operation, first postoperative anal exhaust and hospital stay, and the amount of intraoperative bleeding was less (P < 0.05). One day after operation, MDA increased and SOD decreased in both groups, but MDA and SOD in observation group were lower and higher than those in control group (P < 0.05). One day after operation, ET, DAO and D-LAC were increased in both groups, but the observation group was lower than the control group (P <0.05). The incidence of postoperative complications was compared between the two groups (P > 0.05). Conclusion Laparoscopic radical gastrectomy has less oxidative stress damage on the body of gastric cancer patients, which is conducive to protecting intestinal mucosal barrier function, promoting postoperative gastrointestinal function recovery and shortening hospital stay.

Objective To analyze the prognostic value of TOAST typing in patients with acute ischemic stroke caused by HMCAS. Methods 184 patients with acute ischemic stroke (HMCAS positive) who underwent mechanical thrombectomy (MT) treatment in our hospital from December 2021 to December 2023 were selected as the study subjects. The TOAST classification of HMCAS acute ischemic stroke was determined based on preoperative and postoperative auxiliary examinations and grouped according to the TOAST classification. Compare the general information, clinical data, postoperative condition, NIHSS score, and mRS score of patients with different TOAST subtypes. Results There was no significant statistical difference in age, gender, and other aspects among patients with different TOAST subtypes (P>0.05). There was no statistically significant difference in the distribution of alcohol abuse, family history of stroke, and homocysteinemia among different TOAST subtypes (P>0.05); The distribution of smoking, hypertension, hyperlipidemia, diabetes, coronary heart disease and uric acid levels in different TOAST classifications was statistically different (P<0.05). The distribution of mTICI grading and symptomatic intracranial hemorrhage showed statistical differences among different TOAST subtypes (P<0.05). The number of patients in the SOE group was relatively small and further statistical analysis was not conducted; Compared with other TOAST subtypes, the CE group had significantly higher preoperative and 2-hour postoperative NIHSS scores, as well as 3-month postoperative mRS scores, and the differences were statistically significant (P<0.05); Compared with other TOAST subtypes, the SAA group had significantly lower preoperative and 2-hour postoperative NIHSS scores, as well as 3-month postoperative mRS scores, and the differences were statistically significant (P<0.05). Conclusion TOAST typing is helpful in evaluating the prognosis of mechanical thrombectomy (MT) treatment in patients with acute ischemic stroke (HMCAS positive).

Objective To investigate the risk factors of anticipatory grief in spouses of middle-aged and young patients with advanced cancer, so as to explore the nursing countermeasures in clinical practice. Methods The Chinese version of the anticipatory Grief Scale, the Care Burden Scale, the mental resilience scale and the social support rating Scale were used to investigate the spouses of 252 middle-aged and young patients with advanced cancer. Results The anticipatory sadness score of the spouses of the surveyed patients was 86.03±10.10. The spouses of the female patients, the spouses of the young and middle-aged patients with advanced cancer with low education level, low social support level, poor mental toughness, low awareness of the disease, and more serious diagnosis of the disease were the influencing factors of anticipatory sadness in this group. Conclusion For spouses of young and middle-aged patients with advanced cancer, due to their higher levels of anticipatory grief, healthcare professionals should focus on women and the group of spouses of young and middle-aged patients with advanced cancer who have low levels of culture and social support, poor psychological resilience, a more severe diagnosis of the patient's disease, and a low level of knowledge of the disease in the course of care, and adopt effective, targeted interventions according to needs.

Objective To investigate the occurrence and influencing factors of feeding intolerance (FI) in mechanically ventilated premature infants in neonatal intensive care unit (NICU). Methods A total of 88 premature infants receiving mechanical ventilation in NICU of Jiangxi Children's Hospital from February 2021 to October 2023 were selected to collect data and investigate the occurrence of FI in premature infants with mechanical ventilation in NICU. Children with FI were included in FI group and those without FI were included in non-FI group. Logistic regression analysis was performed for items with statistical differences to identify the risk factors affecting the occurrence of FI in premature infants with NICU mechanical ventilation. Results FI occurred in 29 (32.95%) of the 88 neonates ventilated by NICU, while FI did not occur in 59 (67.05%). Univariate analysis showed that FI was associated with intrauterine distress, gestational age, birth weight, jaundice, milk opening time, neonatal respiratory distress and milk dosage in neonates with NICU mechanical ventilation (P<0.05). Gender, premature rupture of membranes, intrauterine infection, feeding pattern, neonatal pneumonia and anemia were not associated with the occurrence (P>0.05). Multiple Logistic regression analysis showed that gestational age < 32 weeks (OR=16.900, 95% CI: 4.555~62.699), birth weight < 1500g (OR=2.879, 95%CI: 1.139~7.278), intrauterine distress (OR=4.114, 95%CI: 1.208~14.017), milk opening time ≥72h (OR=3.291, 95%CI: 1.102~9.835), jaundice (OR=5.180, 95%CI: 1.822~14.721), neonatal respiratory distress (OR=4.415, 95%CI: 1.673~11.650) and milk dosage > 20ml/kg (OR=3.355, 95%CI: 1.153~9.768) were high risk factors for FI in premature infants mechanically ventilated by NICU (P<0.05). Conclusion Premature infants with NICU mechanical ventilation are prone to FI, and its occurrence is related to gestational age, birth weight, intrauterine distress, milk opening time, jaundice, neonatal respiratory distress, and milk dosage. According to the above factors, the development of corresponding intervention strategies may reduce or avoid FI in premature infants.

Objective To observe the efficacy and outcomes of dapagliflozin in the treatment of patients with chronic heart failure (CHF) complicated with type 2 diabetes mellitus (T2DM). Methods Eighty patients with CHF complicated with T2DM admitted to our hospital and the Affiliated Hospital of Qingdao University were selected and divided into control group (conventional treatment group), combined with dapagliflozin group, sacubitril/valsartan treatment group according to the random number method. The changes of relevant indicators, clinical efficacy and follow-up results of each group before and after treatment were analyzed. Results After treatment, the fasting blood glucose (FBG), N terminal brain natriuretic peptide precursor (NT-praBNP), left ventricular ejection fraction (LEFV), 6-minute walking distance were statistically significant (P < 0.05). After 6 months of hospitalization, the total effective rate of the two groups was compared, and the difference was statistically significant (P < 0.01). The total effective rate of the combined treatment group was higher than that of the conventional treatment group. sacubitril/valsartan combined treatment group was significantly better than that in the control group. Conclusion Dapagliflozin combined with sacubitril/valsartan treatment can effectively improve the clinical efficacy, effectively control blood glucose, and reduce the readmission rate of heart failure and the incidence of major adverse cardiovascular events (MACE).

目的 近年来,随着国内外研究者们对跌倒恐惧与跌倒之间相关性分析的深入研究逐渐增多,并在这一领域取得了较为显著的进展,但针对这些进展和热点进行文献计量分析的研究却相对较少。因此,本研究利用中国知网的可视化功能,旨在全面分析这一领域的研究现状,探索其发展趋势和新兴热点。方法 以中国知网数据库为主,检索自2008年1月1日~2024年1月1日公开发表的有关老年人跌倒恐惧与跌倒的相关文献,并对其进行可视化分析。结果 通过对这些文献的关键词、作者共现网络、基金项目和发文机构进行详细分析,结果发现国内在这一领域的研究呈现出持续上升的趋势,且发文质量较高。这一结果表明,越来越多的学者和机构开始关注老年人的跌倒恐惧与跌倒问题,并为此进行了深入的研究和探讨。结论 关于老年人跌倒及其伴随的跌倒恐惧问题,已经成为一个广受瞩目的研究热点,并且其关注度呈现出持续上升的趋势。因此,本研究通过深入的文献计量学分析,为更有效地预防老年人跌倒,各相关机构之间亟须加强协作,共同推动该领域的研究进展与发展。

Objective To explore the effectiveness of vitamin D (VD) supplementation and height growth in prepubescent children. Method 330 prepubescent children who underwent height promotion at Jinjiang Hospital from June 2021 to June 2023 were selected and divided into three groups based on their VD levels: sufficient group, insufficient group, and deficient group, with 110 cases in each group. According to the guidelines, the sufficient group should be given 400 units of VD orally per day, the insufficient group should be given 800 units of VD orally per day, and the deficient group should be given 2000 units of VD orally per day for 3 months before switching to 800 units of VD orally per day. Record the height, weight, rate of motor dysfunction, rate of short stature, bone density, and serum 25 hydroxyvitamin D [25 (OH) D] of the enrolled subjects. The results showed that before treatment, the height, weight, and bone density of the sufficient group were higher than those of the insufficient group and the deficient group, while the rates of motor dysfunction and short stature were lower than those of the insufficient group and the deficient group. However, the height, weight, and bone density of the insufficient group were higher than those of the deficient group, while the rates of motor dysfunction and short stature were lower than those of the deficient group, with statistical differences (P<0.05); There was no statistically significant difference (P>0.05) in height, weight, 25 (OH) D, bone density, and rates of motor dysfunction and short stature among the three groups after VD supplementation. Conclusion VD supplementation in prepubescent children can effectively promote height growth, increase weight, improve bone density, and reduce the rates of motor dysfunction and short stature.