Kou Anyu, Sun Ning, Li Dong
Objective To observe the application effect of Stereotactic Radiosurgery(SRS)on patients with glioma. Methods A prospective clinical controlled trial was conducted on 120 patients with glioma in our hospital from January 2023 to June 2024. After generating random sequence by computer grouping method,the patients were divided into conventional group and minimally invasive group,with 60 cases in each group. The conventional group received conventional craniotomy for glioma resection,and the minimally invasive group received SRS treatment. The patients were followed-up for half a year. The clinical indicators,blood-brain-barrier function,neurological function and complications of the two groups were compared. Results Under different treatment schemes,the operation time,anesthesia time,intraoperative blood loss,ICU stay time,ambulation time and hospitalization time of the minimally invasive group were lower than those of the conventional group (t=14.227,16.935,43.983,12.804,16.160,4.789;P< 0.05). The MMP9 in the minimally invasive group was lower than that in the conventional group,Occludin(OCLN),Zonula Occludens1(ZO-1),CTⅣ was higher than that of the conventional group (t=3.486,2.710,3.152,3.434;P< 0.05). The levels of GFAP,NSE,NF-L and S100 β in the minimally invasive group were lower than those in the conventional group (t=15.257,3.423,3.533,2.578;P< 0.05). By the end of follow-up,the incidence of complications in the minimally invasive group was 8.33% (5/60),which was lower than 23.33%(14/60)in the conventional group (χ2=5.065;P< 0.05). Conclusion SRS can improve the operation efficiency of patients with glioma,and accelerate the postoperative rehabilitation process of patients,which can effectively reduce blood-brain-barrier injury and nerve function injury,and also has a positive impact on reducing the risk of complications.