Current Issue

  • Select all
    |
  • The impact of seamless management combined with programmatic health education on the mastery of PICC catheterization related knowledge and complications in patients with acute leukemia
    Zhou Jingran, Liu Shuting, Li Yanshan, Xiong Suyun
    2025, 57(1): 1-5. https://doi.org/10.3969/j.issn.1006-5571.2025.01.001
    Download PDF ( )   Knowledge map   Save
    Objective To explore the impact of seamless management combined with procedural health education on the knowledge and complications related to peripheral venous catheterization (PICC) in patients with acute leukemia. Methods 62 patients with acute leukemia admitted to the Second Affiliated Hospital of Nanchang University from March 2021 to September 2023 were selected and randomLy divided into two groups of 31 each using a random number table. The control group received routine intervention,while the observation group implemented seamless management throughout the process combined with procedural health education. Compare the mastery of PICC replacement related knowledge,negative emotions,complications,and quality of life between two groups. Results The observation group had a higher mastery of PICC catheterization related knowledge and a lower incidence of complications compared to the control group (P<0.05);Compare the negative emotions and quality of life between the two groups before intervention (P>0.05);After intervention,the scores of the Self Rating Depression Scale (SDS) and Self Rating Anxiety Scale (SAS) in the observation group were lower than those in the control group,while the scores of each dimension in the WHO Quality of Life Inventory (WHOQOL-BREF) were higher than those in the control group (P<0.05). Conclusion The seamless management of the entire process combined with procedural health education can improve the mastery of PICC catheterization related knowledge in patients with acute leukemia,reduce negative emotions,minimize complications,and improve their quality of life.
  • Exploration of the superiority of using CYP3A5 *3 gene polymorphism detection in the treatment of idiopathic membranous nephropathy with tacrolimus
    Kong Yue, Wu Man, Wu Wenliang, Li Jing
    2025, 57(1): 6-12. https://doi.org/10.3969/j.issn.1006-5571.2025.01.002
    Download PDF ( )   Knowledge map   Save
    Objective To explore the superiority of CYP3A5*3 gene polymorphism detection in the treatment of idiopathic membranous nephropathy (IMN) with tacrolimus,and provide reference for personalized treatment of IMN patients. Methods 75 patients with IMN were included and divided into three groups based on CYP3A5*3genotype：AA,AG,and GG. All patients received tacrolimus treatment with an initial dose of 0. 05 mg/kg•d,twice daily,and the dose was adjusted based on blood drug concentration during the 6-month treatment period. The study simultaneously monitored the levels of urinary protein,plasma albumin,renal function indicators (urea nitrogen,serum creatinine),as well as the levels of inflammatory markers IL-6 and TNF-αin patients. Results After treatment,the total effective rates of AA,AG,and GG patients were 72%,88%,and 92%,respectively. The total effective rates of AG and GG patients were significantly higher than those of AA patients (P<0.05). After treatment,the 24-hour urinary protein,urea nitrogen,and serum creatinine levels of the three groups of patients significantly decreased compared to before treatment. Both AG and GG patients showed a significant decrease compared to AA patients (P<0.05). The plasma albumin,AST,and ALT levels of the three groups of patients significantly increased or decreased after treatment (P<0.05). The plasma albumin levels of AG and GG patients were significantly higher than those of AA patients (P<0.05),while the AST and ALT levels were significantly lower than those of AA patients (P<0.05). The levels of IL-6 and TNF - α in AG and GG patients were significantly reduced compared to before treatment,and were significantly lower than those in the AA group（P<0.05）. Conclusion CYP3A5*3 gene polymorphism detection can effectively guide the application of tacrolimus in IMN patients,optimize drug dosage,improve efficacy,reduce adverse reactions,and provide important reference for personalized treatment.
  • An investigation into the high-risk factors affecting the occurrence of acute kidney injury in patients with sepsis and their protective strategies
    Chen Huafen, Chen Xiaomao, Chen Chunyan, Zheng Yinbi, Chen Mingdi, Jiang Guodong, Chen Guimei
    2025, 57(1): 13-18. https://doi.org/10.3969/j.issn.1006-5571.2025.01.003
    Download PDF ( )   Knowledge map   Save
    Objective To explore the high-risk factors affecting the occurrence of acute kidney injury in patients with sepsis,and to target and analyse protective measures. Methods We retrospectively analysed the clinical data of 84 sepsis patients admitted to the Second Affiliated Hospital of Guangdong Medical University from June 2022 to June 2024,and classified them into occurrence group and non-occurrence group according to the occurrence of acute kidney injury,and collected general data such as patients' gender,age,mechanical ventilation,history of smoking,history of alcohol consumption,history of chronic renal disease,comorbid malnutrition,Acute Physiology and Chronic Health Condition Scoring System II score ( APACHE II) score,cystatin level and other general information to carry out logistic regression analysis to analyse the high-risk factors affecting the occurrence of acute kidney injury in sepsis patients. Results Among 84 patients with sepsis,28 cases of acute kidney injury occurred,with an incidence rate of 33.33%. Univariate factors showed no statistical difference between the two groups in terms of gender,age,mechanical ventilation,smoking history,alcohol consumption history,and combined diabetes mellitus (P>0.05);statistically significant differences were found in the two groups in terms of combined lung infections,combined hyperlactatemia,history of chronic renal disease,combined malnutrition,APACHE II scores,cystatin levels,and other general information. cystatin levels were statistically different (P<0.05);combined lung infection,combined hyperlactatemia,history of chronic kidney disease,combined malnutrition,APACHE II score≥ 18,and cystatin≥2 mg/L were all high-risk factors for the occurrence of acute kidney injury in patients with sepsis (P<0.05). Conclusion Acute kidney injury in patients with sepsis is associated with combined lung infection,combined hyperlactatemia,history of chronic kidney disease,combined malnutrition,APACHE II score,and cystatin level. The clinic needs to take protective measures accordingly to reduce the risk of acute kidney injury.
  • Effectiveness analysis of single-port thoracoscopic lobectomy in treating elderly patients with lung cancer
    Cheng Li, Yang Zhang, Wang Boyuan
    2025, 57(1): 19-23. https://doi.org/10.3969/j.issn.1006-5571.2025.01.004
    Download PDF ( )   Knowledge map   Save
    Objective To analyze the effect of single-port thoracoscopic lobectomy (VATS) in treating elderly patients with lung cancer． Methods The data of 94 cases of elderly patients with lung cancer admitted to our hospital (from June 2022 to August 2024) were collected and retrospective analysed,which were divided into the control group (47 cases) and the observation group (47 cases) according to the differences in surgical protocols;Patients in the control group were treated with the traditional multi-hole VATS,and patients in the observation group were treated with the single-hole VATS;The surgical-related indexes and the complication rates of the two groups were compared,and the effect of single-hole thoracoscopic lobectomy (VATS) on elderly patients with lung cancer in the postoperative period were analyzed．The pain degree of the two groups was compared at different time points (6 h,12 h,24 h,48 h) after surgery by visual analog scale (VAS);Before and 1 d after surgery,the inflammatory indexes [C-reactive protein (CRP),interleukin-6 (IL-6),serum amyloid A (SAA)],and immune function [immunoglobulin (Ig) G (IgG),IgA,IgM] of the two groups were compared． Results Compared with the control group,the observation group had less intraoperative bleeding and shorter hospitalization time (P<0.05),also had lower VAS scores at different postoperative time points (P<0.05),At 1d postoperatively,the levels of CRP,IL-6,and SAA were increased in both groups,but they were lower in the observation group than in the control group (P<0.05),meanwhile,the levels of IgG,IgA,and IgM in both groups were decreased,but they were higher in the observation group than in the control group (P<0.05);There was no statistical difference in the surgical time,the number of lymph node dissection and complications between the two groups (P>0.05)． Conclusion Single-port VATS treatment for elderly patients with lung cancer is more conducive to reducing the degree of surgical pain,decreasing the amount of bleeding,reducing the inflammatory reaction caused by surgery and the damage of immune function,and promoting the recovery of patients．
  • Effect of meropenem infusion at different time on sepsis in elderly patients and its effect on renal function
    Guo wei, Hao xin, Tan dandan, Guo jinyan, Ma Ning, Lan Yuhuai
    2025, 57(1): 24-28. https://doi.org/10.3969/j.issn.1006-5571.2025.01.005
    Download PDF ( )   Knowledge map   Save
    Objective To analyze the effect of Meropenem infusion at different time in the treatment of elderly sepsis and its preventive effect on acute kidney injury. Methods 60 patients with sepsis admitted to our hospital from October 2022 to March 2024 were randomly divided into two groups,30 cases in the observation group and 30 cases in the control group;The control group was infused with Meropenem within 30 minutes,and the observation group was infused with Meropenem within 3 hours. The differences of oxidative stress,inflammatory indexes and renal function injury indexes between the two groups were compared. Results The total effective rate of the observation group was higher than that of the control group (P>0.05);Before treatment,there was no significant difference in renal function injury between the two groups (P>0.05);After treatment,the renal function indexes of the observation group were lower than those of the control group (P>0.05);There was no difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Extending Meropenem in the treatment of elderly sepsis to 3 hours can improve the curative efficacy and safety.
  • Discussion on etiology and pathogenesis of 456 cases of Brucellosis in shandong province
    Liu Qian, Sun Luyan, Yuan Chengmin
    2025, 57(1): 29-34. https://doi.org/10.3969/j.issn.1006-5571.2025.01.006
    Download PDF ( )   Knowledge map   Save
    Objective To summarize and analyze the clinical characteristics and Chinese medicine syndrome characteristics of Brucellosis in order to provide basis for clinical diagnosis and treatment. Methods The clinical data of 456 Brucellosis patients admitted from Shandong Public Health Clinical Center from October 2020 to May 2023,including epidemiology,clinical symptoms,signs and related laboratory tests,were collected and analyzed retrospectively. Results Among the 456 cases,315 were males and 141 were females. The average age was (48.77±15.58）years,the minimum was 4 months and 2 days,and the maximum was 81 years. The common clinical symptoms are fever with joint pain,sweating,and fatigue,which belong to the category of epidemic diseases in Traditional Chinese medicine,and the main causative factors are dampness and heat,which can also be combined with wind,phlegm and stasis,and for a long time,it will consume qi,blood,yin and yang,and liver and kidney deficiency will be the mainstay. Conclusion In the treatment of Brucellosis in Traditional Chinese medicine,the clinical effect is remarkable,which is for reference.
  • Construction of a risk prediction index system for deep vein thrombosis after joint replacement based on Delphi expert consultation method
    Gu Yue, Ma Shasha, Li Xuexin, Liu Wenying, Wang Tianbei
    2025, 57(1): 35-41. https://doi.org/10.3969/j.issn.1006-5571.2025.01.007
    Download PDF ( )   Knowledge map   Save
    Objective To construct risk prediction and evaluation indicators of deep vein thrombosis after joint replacement,and provide basis for prevention and evaluation of deep vein thrombosis. Methods To determine the risk prediction index system of deep vein thrombosis after joint replacement through literature review and Delphi expert consultation. Results This study conducted a total of two rounds of expert inquiry,with an effective response rate of 100%. The authority coefficients of the two rounds of expert inquiry were 0.84 and 0.86 respectively,and Kendall's W values were 0.337 and 0.252. The final risk prediction index system of deep vein thrombosis after joint replacement includes 5 first level indicators and 28 second level indicators. Conclusion The risk prediction index system of deep vein thrombosis after joint replacement is highly scientific and practical,which can provide a reliable basis for the prevention of deep vein thrombosis in patients after joint replacement.
  • Expression and clinicopathologic significance of TBK1 in colorectal cancer
    Lu Huadong, Jiang Qiuli, Chen Huan, Hou Jun, Liu Kun
    2025, 57(1): 42-47. https://doi.org/10.3969/j.issn.1006-5571.2025.01.008
    Download PDF ( )   Knowledge map   Save
    Objective To investigate the expression and clinicopathologic significance of TBK1 in colorectal cancer. Methods A retrospective study was conducted among 80 patients with colorectal cancer who underwent radical resection in the hospital from March 2022 to February 2024. The expression of TBK1 in cancerous tissues and adjacent normal tissues was detected by immunohis to chemical staining. The relationship between TBK1 expression and clinicopathological factors in colorectal cancer was analized. Results The positive rates of TBK1 expression in cancerous tissues and adjacent normal tissues of the 80 patients with colorectal cancer were 78.75% (63/80) and 6.00% (5/80) respectively,which had statistically significant difference (P<0.05). There was no significant difference in TBK1 expression between patients of different gender and different age (P>0.05),but there were statistically significant differences between patients in TNM stages,differentiation degrees,lymph node metastasis and depth of infiltration (P<0.05). Conclusion TBK1 is highly expressed in colorectal cancer and correlated with TNM staging and differentiation degree,which suggests that TBK1 may play an important role in the development and progression of colorectal cancer.
  • Objective to compare the curative effect and functional recovery of support plate and hollow lag screw fixation in the treatment of posterior ankle fracture
    Zhang Minhang, Liang Wenhao, Wang Yi, Xin Xiaolin
    2025, 57(1): 48-52. https://doi.org/10.3969/j.issn.1006-5571.2025.01.009
    Download PDF ( )   Knowledge map   Save
    Objective To investigate the efficacy and postoperative recovery of posterior ankle fixation with supporting splints and hollow tension screws in the treatment of triple ankle fractures. Methods This paper retrospectively analysed the data of 106 patients with triple ankle fracture admitted to our hospital between June 2021 and June 2023,50 patients treated with supportive bone grafting plate were in the supportive plate group,and 56 patients fixed with hollow tension screws were in the hollow nail group. The operation、 recovery-related indexes and the ocurrence of complications were compared between the two groups. Postoperative pain level and recovery of ankle function in these patients were evaluated by VAS and AOFAS scoring systems. Results The healing time of posterior ankle fracture was significantly shorter in the braced plate group than in the hollow nail group (P<0.05);at 6 months after surgery,the VAS score and AOFAS score of the patients in the braced plate group were better than those in the hollow nail group (P<0.05),which indicated that braced splint fixation was more conducive to the recovery of the patients;at 6 months after surgery,the incidence of the total complication rate in the braced plate fixation group was 12.00%,while that in the hollow nail group The total complication rate was 8.93%,and there was no significant statistical difference between the two groups (P>0.05). Conclusion Supported splint and hollow tension screw fixation in the posterior-lateral approach are commonly used fixation Methods in the treatment of triple ankle fractures. Although both Methods can achieve good clinical Results,braced splint fixation shows higher stability and superiority when dealing with more complex posterior ankle fractures,which helps patients to start functional exercises in the early postoperative period,thus accelerating the rehabilitation process.
  • Diagnostic value of transvaginal color doppler ultrasound combined with TUI technology in early ectopic pregnancy
    Dong Xiangjun, Zhang Jian, Qin Weihong
    2025, 57(1): 53-58. https://doi.org/10.3969/j.issn.1006-5571.2025.01.010
    Download PDF ( )   Knowledge map   Save
    Objective To investigate the diagnostic value of transvaginal color Doppler ultrasound (TVCDS) combined with tomographic ultrasound imaging (TUI) technology in early ectopic pregnancy. Methods A retrospective study was conducted on 107 pregnant women with suspected early ectopic pregnancy admitted to our hospital from March 2023 to May 2024. Using diagnostic curettage as the “gold standard”,the diagnostic efficacy of TVCDS and TVCDS combined with TUI technology was compared,as well as their diagnostic accuracy for the location of pregnancy. The image detection of different types of fallopian tubes using TVCDS combined with TUI technology was compared. Results The accuracy,sensitivity,and negative predictive value of TVCDS combined with TUI technology for diagnosing ectopic pregnancy were 91.59%,95.59% and 91.67%,respectively,which were higher than those of TVCDS alone (80.37%,83.82% and 72.50%). The missed diagnosis rate of TVCDS combined with TUI technology was 4.41%,which was lower than that of TVCDS alone (16.18%),and the differences were statistically significant (P<0.05). The TVCDS and diagnostic curettage of ectopic pregnancy showed moderate consistency (Kappa=0.579),and the Results of TVCDS combined with TUI technology were almost consistent with diagnostic curettage of ectopic pregnancy (Kappa=0.815). The coincidence rate of TVCDS combined with TUI technology for tubal pregnancy was higher than that of TVCDS alone,and the difference was statistically significant (P<0.05). There was no statistical difference in the diagnostic accuracy between TVCDS alone and TVCDS combined with TUI technology for diagnosing cornual pregnancy and intrauterine pregnancy (P>0.05). The detection of unruptured,ruptured,and miscarried types of pregnancy using TVCDS combined with TUI technology in terms of boundary,internal clarity,yolk sac,and detection rate of primitive heart tube showed significant differences (P<0.05). Conclusion TVCDS combined with TUI technology has better diagnostic value for early ectopic pregnancy,which can provide some auxiliary reference value for clinical diagnosis of early ectopic pregnancy.
  • The risk prediction model of lower extremity deep vein thrombosis in patients with spontaneous cerebral hemorrhage was constructed based on machine learning
    Liu Wenying, Wang Shaohua, Ma Shasha
    2025, 57(1): 59-64. https://doi.org/10.3969/j.issn.1006-5571.2025.01.011
    Download PDF ( )   Knowledge map   Save
    Objective To construct a risk prediction model for lower extremity deep vein thrombosis (DVT) in patients with spontaneous cerebral hemorrhage and verify the model internally. Methods A total of 436 patients with spontaneous cerebral hemorrhage who were hospitalized in the Department of Neurosurgery of a tertiary general hospital in Shandong Province from June 2020 to May 2023 were selected as the subjects of the modeling group. Patients were divided into DVT group and non-DVT group according to whether they had DVT or not. With the occurrence of DVT as the target variable and the factors determined by Logistic regression model as input variables,input R-Studio 4.1.2 software,call the rpart extension package,build the model based on CART classification tree,and pruning the tree according to complexity parameter (CP) to deal with redundant branches. Finally,a complete decision tree was formed and the effect of the model was verified to predict the risk of DVTLE in ICH patients. Results The Results of CART prediction model showed that the independent risk factors for DVTLE in ICH patients were age,BMI,smoking history,central vein indentation,lower limb muscle strength at admission,and bed rest time in descending order of importance. The area under ROC curve of CART model was 0.768 (95%CI= 0.735~0.802,P<0.001),the maximum approximate entry index was 0.419,the sensitivity was 70.49%,and the specificity was 71. 42%. Bootstrap internal verification showed that the consistency index C-index was 0.711 (95%CI：0.656~0.768). Conclusion The CART model for predicting the risk of lower extremity deep vein thrombosis in patients with spontaneous cerebral hemorrhage based on machine learning has high predictive value and is worthy of clinical application.
  • The influence of blood composition on the pattern of blood evaporation and the rapid research and diagnosis of children with diabetes
    Lu Chun, Guo Zhouping, Chen Nenghui
    2025, 57(1): 65-70. https://doi.org/10.3969/j.issn.1006-5571.2025.01.012
    Download PDF ( )   Knowledge map   Save
    Blood evaporation patterns are unique traces or patterns of blood during the evaporation process,which reflect the distribution and concentration characteristics of blood components. Under normal health and pathological conditions,the proportion and state of blood components often change,thereby affecting the formation of blood evaporation patterns. By quantitatively analyzing the patterns of blood evaporation,researchers may be able to identify changes in blood composition and speculate about the possible pathological changes. This analysis can not only provide new clues for disease diagnosis,but also improve the accuracy of early diagnosis of diseases,especially for early detection of diabetes and its related complications. The purpose of this project is to study the relationship between blood evaporation pattern and children's diabetes,and explore its early diagnosis application. Therefore,this project will deeply study the influence mechanism of various blood components on blood evaporation pattern,so as to promote the development of new diagnostic technology for children with diabetes.
  • Reflections and discussions on physician-patient communication in prehospital emergency care
    Zhang Lingyan, Mu Bin, Jiao Xin
    2025, 57(1): 71-74. https://doi.org/10.3969/j.issn.1006-5571.2025.01.013
    Download PDF ( )   Knowledge map   Save
    Objective Prehospital emergency care is an important part of the emergency medical service system characterized by suddenness,urgency,difficulty,and high risk. There are also more medical disputes caused by some inappropriate behaviors in prehospital emergency care. With the continuous progress of society and people's increasing legal awareness,the issue of doctor-patient communication has gradually attracted more and more people's attention. The special nature of this communication is reflected in the fact that emergency personnel not only need to quickly assess the patient's condition and take effective emergency measures in time,but also need to communicate effectively with the patient and his family to obtain their understanding and cooperation. This paper analyzes the importance,characteristics,difficulties,and problems of doctor-patient communication in prehospital emergency care,and puts forward strategies and suggestions for strengthening doctor-patient communication and preventing medical disputes.
  • Exploration and practice of the reasonable application of traditional Chinese medicine injections of Leshan Hospital of Traditional Chinese Medicine
    Liu Yuzhu, Zhang Fudong, Zhu Minfeng
    2025, 57(1): 75-80. https://doi.org/10.3969/j.issn.1006-5571.2025.01.014
    Download PDF ( )   Knowledge map   Save
    Objective To explore the ways to improve the reasonable application level of traditional Chinese medicine (TCM) injections in Leshan Hospital of Traditional Chinese Medicine. Methods Based on the data collected in Leshan Hospital of Traditional Chinese Medicine from January 2023 to June 2023,the situation of unreasonable application were analyzed,the problem types with high proportion of the situation of unreasonable application in TCM injections were identified and analyzed,and the corresponding management system and measures were formulated. Results 214 out of 1000 medical records used TCM injections,of which 102 were used unrationally,accounting for 47. 66%. According to the characteristics and problems in clinical application of TCM injections,after the modification by clinical pharmacist from July 2023 to December 2023,some practical management systems and safeguard measures are formulated,and the unrational drug use rate fell to 18.75%. Conclusion In the treatment of TCM injections,the analysis of irrational clinical incompatibility should be strengthened,and effective improvement strategies should be put forward based on the clinical practice,so as to improve the rationality of drug use and provide guidance for the application of TCM injections.